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Collective cancer cell invasion requires RNA accumulation at the invasive front
Localization of RNAs at protrusive regions of cells is important for single-cell migration on two-dimensional surfaces. Protrusion-enriched RNAs encode factors linked to cancer progression, such as the RAB13 GTPase and the NET1 guanine nucleotide exchange factor, and are regulated by the tumor-suppr...
Autores principales: | Chrisafis, George, Wang, Tianhong, Moissoglu, Konstadinos, Gasparski, Alexander N., Ng, Yeap, Weigert, Roberto, Lockett, Stephen J., Mili, Stavroula |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959543/ https://www.ncbi.nlm.nih.gov/pubmed/33060293 http://dx.doi.org/10.1073/pnas.2010872117 |
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