COVID-19 mRNA vaccines

The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical asse...

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Detalles Bibliográficos
Autores principales: Huang, Qingrui, Zeng, Jiawei, Yan, Jinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959685/
https://www.ncbi.nlm.nih.gov/pubmed/34006471
http://dx.doi.org/10.1016/j.jgg.2021.02.006
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author Huang, Qingrui
Zeng, Jiawei
Yan, Jinghua
author_facet Huang, Qingrui
Zeng, Jiawei
Yan, Jinghua
author_sort Huang, Qingrui
collection PubMed
description The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges.
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spelling pubmed-79596852021-03-16 COVID-19 mRNA vaccines Huang, Qingrui Zeng, Jiawei Yan, Jinghua J Genet Genomics Review The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. 2021-02-20 2021-03-15 /pmc/articles/PMC7959685/ /pubmed/34006471 http://dx.doi.org/10.1016/j.jgg.2021.02.006 Text en © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Huang, Qingrui
Zeng, Jiawei
Yan, Jinghua
COVID-19 mRNA vaccines
title COVID-19 mRNA vaccines
title_full COVID-19 mRNA vaccines
title_fullStr COVID-19 mRNA vaccines
title_full_unstemmed COVID-19 mRNA vaccines
title_short COVID-19 mRNA vaccines
title_sort covid-19 mrna vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959685/
https://www.ncbi.nlm.nih.gov/pubmed/34006471
http://dx.doi.org/10.1016/j.jgg.2021.02.006
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