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Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps

Hydroxymethylbilane synthase (HMBS), which is involved in the heme biosynthesis pathway, has a dipyrromethane cofactor and combines four porphobilinogen (PBG) molecules to form a linear tetrapyrrole, hydroxymethylbilane. Enzyme kinetic study of human HMBS using a PBG-derivative, 2-iodoporphobilinoge...

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Detalles Bibliográficos
Autores principales:	Sato, Hideaki, Sugishima, Masakazu, Tsukaguchi, Mai, Masuko, Takahiro, Iijima, Mikuru, Takano, Mitsunori, Omata, Yoshiaki, Hirabayashi, Kei, Wada, Kei, Hisaeda, Yoshio, Yamamoto, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959689/ https://www.ncbi.nlm.nih.gov/pubmed/33600566 http://dx.doi.org/10.1042/BCJ20200996

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