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Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy

Crosstalk of the oncogenic matrix metalloproteinase-9 (MMP9) and one of its ligands, CD44, involves cleavage of CD44 by the MMP9 catalytic domain, with the CD44–MMP9 interaction on the cell surface taking place through the MMP9 hemopexin domain (PEX). This interaction promotes cancer cell migration...

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Detalles Bibliográficos
Autores principales:	Yosef, Gal, Hayun, Hezi, Papo, Niv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959692/ https://www.ncbi.nlm.nih.gov/pubmed/33600567 http://dx.doi.org/10.1042/BCJ20200628

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