A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy

It remains undefined whether a subset of CD4+ T cells can function as fast-acting cells to control Mycobacterium tuberculosis (Mtb) infection. Here we show that the primary CD4+CD161+ T-cell subset, not CD4+CD161-, in unexposed healthy humans fast acted as unconventional T cells capable of inhibitin...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Peng, Ying, Pi, Jiang, Liu, Yidian, Yang, Enzhuo, Shen, Xiaona, Yao, Lan, Shen, Ling, Modlin, Robert L., Shen, Hongbo, Sha, Wei, Chen, Zheng W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959736/
https://www.ncbi.nlm.nih.gov/pubmed/33732233
http://dx.doi.org/10.3389/fimmu.2021.599641

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