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Imaging of Vulva Syringoma With Reflectance Confocal Microscopy

Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma. Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM...

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Autores principales: Feng, Lin, Lin, Yan, Wang, Leilei, Chen, Hongxiao, Gao, Min, Liu, Huaxu, Yang, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959786/
https://www.ncbi.nlm.nih.gov/pubmed/33732725
http://dx.doi.org/10.3389/fmed.2021.649438
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author Feng, Lin
Lin, Yan
Wang, Leilei
Chen, Hongxiao
Gao, Min
Liu, Huaxu
Yang, Hongyu
author_facet Feng, Lin
Lin, Yan
Wang, Leilei
Chen, Hongxiao
Gao, Min
Liu, Huaxu
Yang, Hongyu
author_sort Feng, Lin
collection PubMed
description Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma. Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation. Results: Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1–2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images. Conclusions: Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma.
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spelling pubmed-79597862021-03-16 Imaging of Vulva Syringoma With Reflectance Confocal Microscopy Feng, Lin Lin, Yan Wang, Leilei Chen, Hongxiao Gao, Min Liu, Huaxu Yang, Hongyu Front Med (Lausanne) Medicine Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma. Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation. Results: Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1–2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images. Conclusions: Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7959786/ /pubmed/33732725 http://dx.doi.org/10.3389/fmed.2021.649438 Text en Copyright © 2021 Feng, Lin, Wang, Chen, Gao, Liu and Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Feng, Lin
Lin, Yan
Wang, Leilei
Chen, Hongxiao
Gao, Min
Liu, Huaxu
Yang, Hongyu
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title_full Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title_fullStr Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title_full_unstemmed Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title_short Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
title_sort imaging of vulva syringoma with reflectance confocal microscopy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959786/
https://www.ncbi.nlm.nih.gov/pubmed/33732725
http://dx.doi.org/10.3389/fmed.2021.649438
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