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Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome

Because nitric oxide and endothelial dysfunction could play a role in the pathogenesis of idiopathic restless legs syndrome (RLS), as was suggested by some preliminary data, we investigated the possible association between the rs2070744 variants in the endothelial nitric oxide synthase (eNOS or NOS3...

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Autores principales: Jiménez-Jiménez, Félix Javier, Agúndez, Blanca G., Gómez-Tabales, Javier, Alonso-Navarro, Hortensia, Turpín-Fenoll, Laura, Millán-Pascual, Jorge, Díez-Fairén, Mónica, Álvarez, Ignacio, Pastor, Pau, Calleja, Marisol, García-Ruiz, Rafael, Navarro-Muñoz, Santiago, Recio-Bermejo, Marta, Plaza-Nieto, José Francisco, García-Albea, Esteban, García-Martín, Elena, Agúndez, José A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959806/
https://www.ncbi.nlm.nih.gov/pubmed/33732155
http://dx.doi.org/10.3389/fphar.2021.618989
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author Jiménez-Jiménez, Félix Javier
Agúndez, Blanca G.
Gómez-Tabales, Javier
Alonso-Navarro, Hortensia
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Calleja, Marisol
García-Ruiz, Rafael
Navarro-Muñoz, Santiago
Recio-Bermejo, Marta
Plaza-Nieto, José Francisco
García-Albea, Esteban
García-Martín, Elena
Agúndez, José A. G.
author_facet Jiménez-Jiménez, Félix Javier
Agúndez, Blanca G.
Gómez-Tabales, Javier
Alonso-Navarro, Hortensia
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Calleja, Marisol
García-Ruiz, Rafael
Navarro-Muñoz, Santiago
Recio-Bermejo, Marta
Plaza-Nieto, José Francisco
García-Albea, Esteban
García-Martín, Elena
Agúndez, José A. G.
author_sort Jiménez-Jiménez, Félix Javier
collection PubMed
description Because nitric oxide and endothelial dysfunction could play a role in the pathogenesis of idiopathic restless legs syndrome (RLS), as was suggested by some preliminary data, we investigated the possible association between the rs2070744 variants in the endothelial nitric oxide synthase (eNOS or NOS3) gene (chromosome 7q36.1) and the risk for RLS in a Caucasian Spanish population. We assessed the frequencies of NOS3 single nucleotide polymorphisms (SNPs) rs2070744, rs1799983, and rs79467411 genotypes and allelic variants in 273 patients with idiopathic RLS and 325 healthy controls using a TaqMan-based qPCR assay. We also analyzed the possible influence of genotype frequency on age at onset of RLS symptoms, gender, family history of RLS, and response to drugs commonly used in the treatment of RLS such as dopaminergic drugs, clonazepam, and GABAergic drugs. The frequencies of genotypes and allelic variants were not associated with the risk for RLS and were not influenced by gender, age, and positive family history of RLS. We identified weak statistical associations of the SNP rs1799983 with the response to dopamine agonists (Pc = 0.018 for the rs1799983 G/T genotype) and of the SNP rs79467411 with the response to clonazepam (Pc = 0.018 for the rs79467411 G allele), although these findings should be cautiously interpreted and require further confirmation. These associations aside, our findings suggest that common NOS3 SNPs are not associated with the risk for idiopathic RLS in Caucasian Spanish people.
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spelling pubmed-79598062021-03-16 Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome Jiménez-Jiménez, Félix Javier Agúndez, Blanca G. Gómez-Tabales, Javier Alonso-Navarro, Hortensia Turpín-Fenoll, Laura Millán-Pascual, Jorge Díez-Fairén, Mónica Álvarez, Ignacio Pastor, Pau Calleja, Marisol García-Ruiz, Rafael Navarro-Muñoz, Santiago Recio-Bermejo, Marta Plaza-Nieto, José Francisco García-Albea, Esteban García-Martín, Elena Agúndez, José A. G. Front Pharmacol Pharmacology Because nitric oxide and endothelial dysfunction could play a role in the pathogenesis of idiopathic restless legs syndrome (RLS), as was suggested by some preliminary data, we investigated the possible association between the rs2070744 variants in the endothelial nitric oxide synthase (eNOS or NOS3) gene (chromosome 7q36.1) and the risk for RLS in a Caucasian Spanish population. We assessed the frequencies of NOS3 single nucleotide polymorphisms (SNPs) rs2070744, rs1799983, and rs79467411 genotypes and allelic variants in 273 patients with idiopathic RLS and 325 healthy controls using a TaqMan-based qPCR assay. We also analyzed the possible influence of genotype frequency on age at onset of RLS symptoms, gender, family history of RLS, and response to drugs commonly used in the treatment of RLS such as dopaminergic drugs, clonazepam, and GABAergic drugs. The frequencies of genotypes and allelic variants were not associated with the risk for RLS and were not influenced by gender, age, and positive family history of RLS. We identified weak statistical associations of the SNP rs1799983 with the response to dopamine agonists (Pc = 0.018 for the rs1799983 G/T genotype) and of the SNP rs79467411 with the response to clonazepam (Pc = 0.018 for the rs79467411 G allele), although these findings should be cautiously interpreted and require further confirmation. These associations aside, our findings suggest that common NOS3 SNPs are not associated with the risk for idiopathic RLS in Caucasian Spanish people. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7959806/ /pubmed/33732155 http://dx.doi.org/10.3389/fphar.2021.618989 Text en Copyright © 2021 Jiménez-Jiménez, Agúndez, Gómez-Tabales, Alonso-Navarro, Turpín-Fenoll, Millán-Pascual, Díez-Fairén, Álvarez, Pastor, Calleja, García-Ruiz, Navarro-Muñoz, Recio-Bermejo, Plaza-Nieto, García-Albea, García-Martín and Agúndez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jiménez-Jiménez, Félix Javier
Agúndez, Blanca G.
Gómez-Tabales, Javier
Alonso-Navarro, Hortensia
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Calleja, Marisol
García-Ruiz, Rafael
Navarro-Muñoz, Santiago
Recio-Bermejo, Marta
Plaza-Nieto, José Francisco
García-Albea, Esteban
García-Martín, Elena
Agúndez, José A. G.
Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title_full Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title_fullStr Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title_full_unstemmed Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title_short Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome
title_sort common endothelial nitric oxide synthase single nucleotide polymorphisms are not related with the risk for restless legs syndrome
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959806/
https://www.ncbi.nlm.nih.gov/pubmed/33732155
http://dx.doi.org/10.3389/fphar.2021.618989
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