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Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959842/ https://www.ncbi.nlm.nih.gov/pubmed/33732239 http://dx.doi.org/10.3389/fimmu.2021.615748 |