Cargando…

Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ashraf, Ghulam Md, Ebada, Mahmoud Ahmed, Suhail, Mohd, Ali, Ashraf, Uddin, Md. Sahab, Bilgrami, Anwar L., Perveen, Asma, Husain, Amjad, Tarique, Mohd, Hafeez, Abdul, Alexiou, Athanasios, Ahmad, Ausaf, Kumar, Rajnish, Banu, Naheed, Najda, Agnieszka, Sayed, Amany A., Albadrani, Ghadeer M., Abdel-Daim, Mohamed M., Peluso, Ilaria, Barreto, George E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960032/
https://www.ncbi.nlm.nih.gov/pubmed/33747345
http://dx.doi.org/10.1155/2021/4572471
_version_ 1783665052919791616
author Ashraf, Ghulam Md
Ebada, Mahmoud Ahmed
Suhail, Mohd
Ali, Ashraf
Uddin, Md. Sahab
Bilgrami, Anwar L.
Perveen, Asma
Husain, Amjad
Tarique, Mohd
Hafeez, Abdul
Alexiou, Athanasios
Ahmad, Ausaf
Kumar, Rajnish
Banu, Naheed
Najda, Agnieszka
Sayed, Amany A.
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Peluso, Ilaria
Barreto, George E.
author_facet Ashraf, Ghulam Md
Ebada, Mahmoud Ahmed
Suhail, Mohd
Ali, Ashraf
Uddin, Md. Sahab
Bilgrami, Anwar L.
Perveen, Asma
Husain, Amjad
Tarique, Mohd
Hafeez, Abdul
Alexiou, Athanasios
Ahmad, Ausaf
Kumar, Rajnish
Banu, Naheed
Najda, Agnieszka
Sayed, Amany A.
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Peluso, Ilaria
Barreto, George E.
author_sort Ashraf, Ghulam Md
collection PubMed
description The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.
format Online
Article
Text
id pubmed-7960032
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-79600322021-03-19 Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies Ashraf, Ghulam Md Ebada, Mahmoud Ahmed Suhail, Mohd Ali, Ashraf Uddin, Md. Sahab Bilgrami, Anwar L. Perveen, Asma Husain, Amjad Tarique, Mohd Hafeez, Abdul Alexiou, Athanasios Ahmad, Ausaf Kumar, Rajnish Banu, Naheed Najda, Agnieszka Sayed, Amany A. Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Peluso, Ilaria Barreto, George E. Oxid Med Cell Longev Review Article The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains. Hindawi 2021-03-05 /pmc/articles/PMC7960032/ /pubmed/33747345 http://dx.doi.org/10.1155/2021/4572471 Text en Copyright © 2021 Ghulam Md Ashraf et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ashraf, Ghulam Md
Ebada, Mahmoud Ahmed
Suhail, Mohd
Ali, Ashraf
Uddin, Md. Sahab
Bilgrami, Anwar L.
Perveen, Asma
Husain, Amjad
Tarique, Mohd
Hafeez, Abdul
Alexiou, Athanasios
Ahmad, Ausaf
Kumar, Rajnish
Banu, Naheed
Najda, Agnieszka
Sayed, Amany A.
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Peluso, Ilaria
Barreto, George E.
Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title_full Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title_fullStr Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title_full_unstemmed Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title_short Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
title_sort dissecting sex-related cognition between alzheimer's disease and diabetes: from molecular mechanisms to potential therapeutic strategies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960032/
https://www.ncbi.nlm.nih.gov/pubmed/33747345
http://dx.doi.org/10.1155/2021/4572471
work_keys_str_mv AT ashrafghulammd dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT ebadamahmoudahmed dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT suhailmohd dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT aliashraf dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT uddinmdsahab dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT bilgramianwarl dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT perveenasma dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT husainamjad dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT tariquemohd dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT hafeezabdul dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT alexiouathanasios dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT ahmadausaf dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT kumarrajnish dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT banunaheed dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT najdaagnieszka dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT sayedamanya dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT albadranighadeerm dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT abdeldaimmohamedm dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT pelusoilaria dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies
AT barretogeorgee dissectingsexrelatedcognitionbetweenalzheimersdiseaseanddiabetesfrommolecularmechanismstopotentialtherapeuticstrategies