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Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), s...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960032/ https://www.ncbi.nlm.nih.gov/pubmed/33747345 http://dx.doi.org/10.1155/2021/4572471 |
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author | Ashraf, Ghulam Md Ebada, Mahmoud Ahmed Suhail, Mohd Ali, Ashraf Uddin, Md. Sahab Bilgrami, Anwar L. Perveen, Asma Husain, Amjad Tarique, Mohd Hafeez, Abdul Alexiou, Athanasios Ahmad, Ausaf Kumar, Rajnish Banu, Naheed Najda, Agnieszka Sayed, Amany A. Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Peluso, Ilaria Barreto, George E. |
author_facet | Ashraf, Ghulam Md Ebada, Mahmoud Ahmed Suhail, Mohd Ali, Ashraf Uddin, Md. Sahab Bilgrami, Anwar L. Perveen, Asma Husain, Amjad Tarique, Mohd Hafeez, Abdul Alexiou, Athanasios Ahmad, Ausaf Kumar, Rajnish Banu, Naheed Najda, Agnieszka Sayed, Amany A. Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Peluso, Ilaria Barreto, George E. |
author_sort | Ashraf, Ghulam Md |
collection | PubMed |
description | The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains. |
format | Online Article Text |
id | pubmed-7960032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-79600322021-03-19 Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies Ashraf, Ghulam Md Ebada, Mahmoud Ahmed Suhail, Mohd Ali, Ashraf Uddin, Md. Sahab Bilgrami, Anwar L. Perveen, Asma Husain, Amjad Tarique, Mohd Hafeez, Abdul Alexiou, Athanasios Ahmad, Ausaf Kumar, Rajnish Banu, Naheed Najda, Agnieszka Sayed, Amany A. Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Peluso, Ilaria Barreto, George E. Oxid Med Cell Longev Review Article The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains. Hindawi 2021-03-05 /pmc/articles/PMC7960032/ /pubmed/33747345 http://dx.doi.org/10.1155/2021/4572471 Text en Copyright © 2021 Ghulam Md Ashraf et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ashraf, Ghulam Md Ebada, Mahmoud Ahmed Suhail, Mohd Ali, Ashraf Uddin, Md. Sahab Bilgrami, Anwar L. Perveen, Asma Husain, Amjad Tarique, Mohd Hafeez, Abdul Alexiou, Athanasios Ahmad, Ausaf Kumar, Rajnish Banu, Naheed Najda, Agnieszka Sayed, Amany A. Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Peluso, Ilaria Barreto, George E. Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title | Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title_full | Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title_fullStr | Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title_full_unstemmed | Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title_short | Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies |
title_sort | dissecting sex-related cognition between alzheimer's disease and diabetes: from molecular mechanisms to potential therapeutic strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960032/ https://www.ncbi.nlm.nih.gov/pubmed/33747345 http://dx.doi.org/10.1155/2021/4572471 |
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