A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?

Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed hi...

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Detalles Bibliográficos
Autores principales: Tong, Jiankun, Luo, Jean, Saldinger, Pierre F., Rodgers, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960056/
https://www.ncbi.nlm.nih.gov/pubmed/33747577
http://dx.doi.org/10.1155/2021/8856649
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author Tong, Jiankun
Luo, Jean
Saldinger, Pierre F.
Rodgers, William H.
author_facet Tong, Jiankun
Luo, Jean
Saldinger, Pierre F.
Rodgers, William H.
author_sort Tong, Jiankun
collection PubMed
description Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.
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spelling pubmed-79600562021-03-19 A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? Tong, Jiankun Luo, Jean Saldinger, Pierre F. Rodgers, William H. Case Rep Hematol Case Report Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature. Hindawi 2021-03-08 /pmc/articles/PMC7960056/ /pubmed/33747577 http://dx.doi.org/10.1155/2021/8856649 Text en Copyright © 2021 Jiankun Tong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tong, Jiankun
Luo, Jean
Saldinger, Pierre F.
Rodgers, William H.
A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title_full A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title_fullStr A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title_full_unstemmed A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title_short A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
title_sort rare case of histiocytic sarcoma secondary to gastrointestinal stromal tumor in the stomach: transdifferentiation or synchronicity?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960056/
https://www.ncbi.nlm.nih.gov/pubmed/33747577
http://dx.doi.org/10.1155/2021/8856649
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