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Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution
The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear. Here, we screened for SF3B1 mutations in the vicinity of the h...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960499/ https://www.ncbi.nlm.nih.gov/pubmed/33777335 http://dx.doi.org/10.1016/j.csbj.2021.02.012 |