Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery

To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients using the GLIPH2 (grouping of lymphocyte interactions with paratope hotspots 2) algorithm. We identified over 66,000 shared spec...

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Detalles Bibliográficos
Autores principales: Chiou, Shin-Heng, Tseng, Diane, Reuben, Alexandre, Mallajosyula, Vamsee, Molina, Irene S., Conley, Stephanie, Wilhelmy, Julie, McSween, Alana M., Yang, Xinbo, Nishimiya, Daisuke, Sinha, Rahul, Nabet, Barzin Y., Wang, Chunlin, Shrager, Joseph B., Berry, Mark F., Backhus, Leah, Lui, Natalie S., Wakelee, Heather A., Neal, Joel W., Padda, Sukhmani K., Berry, Gerald J., Delaidelli, Alberto, Sorensen, Poul H., Sotillo, Elena, Tran, Patrick, Benson, Jalen A., Richards, Rebecca, Labanieh, Louai, Klysz, Dorota D., Louis, David M., Feldman, Steven A., Diehn, Maximilian, Weissman, Irving L., Zhang, Jianjun, Wistuba, Ignacio I., Futreal, P. Andrew, Heymach, John V., Garcia, K. Christopher, Mackall, Crystal L., Davis, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960510/
https://www.ncbi.nlm.nih.gov/pubmed/33691136
http://dx.doi.org/10.1016/j.immuni.2021.02.014

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