A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

The monocyte β(2)-integrin Mac-1 is crucial for leukocyte–endothelium interaction, rendering it an attractive therapeutic target for acute and chronic inflammation. Using phage display, a Designed-Ankyrin-Repeat-Protein (DARPin) was selected as a novel binding protein targeting and blocking the α(M)...

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Detalles Bibliográficos
Autores principales: Siegel, Patrick M., Bojti, István, Bassler, Nicole, Holien, Jessica, Flierl, Ulrike, Wang, Xiaowei, Waggershauser, Philipp, Tonnar, Xavier, Vedecnik, Christopher, Lamprecht, Constanze, Stankova, Ivana, Li, Tian, Helbing, Thomas, Wolf, Dennis, Anto-Michel, Nathaly, Mitre, Lucia Sol, Ehrlich, Julia, Orlean, Lukas, Bender, Ileana, Przewosnik, Anne, Mauler, Maximilian, Hollederer, Laura, Moser, Martin, Bode, Christoph, Parker, Michael W., Peter, Karlheinz, Diehl, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960600/
https://www.ncbi.nlm.nih.gov/pubmed/33721106
http://dx.doi.org/10.1007/s00395-021-00849-9

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