In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes

In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca(2+)) release plays a cen...

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Autores principales: Ahumada-Castro, Ulises, Bustos, Galdo, Silva-Pavez, Eduardo, Puebla-Huerta, Andrea, Lovy, Alenka, Cárdenas, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960657/
https://www.ncbi.nlm.nih.gov/pubmed/33738285
http://dx.doi.org/10.3389/fcell.2021.629522
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author Ahumada-Castro, Ulises
Bustos, Galdo
Silva-Pavez, Eduardo
Puebla-Huerta, Andrea
Lovy, Alenka
Cárdenas, César
author_facet Ahumada-Castro, Ulises
Bustos, Galdo
Silva-Pavez, Eduardo
Puebla-Huerta, Andrea
Lovy, Alenka
Cárdenas, César
author_sort Ahumada-Castro, Ulises
collection PubMed
description In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca(2+)) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca(2+) communication on organelle function as well as catabolism and anabolism, particularly in cancer.
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spelling pubmed-79606572021-03-17 In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes Ahumada-Castro, Ulises Bustos, Galdo Silva-Pavez, Eduardo Puebla-Huerta, Andrea Lovy, Alenka Cárdenas, César Front Cell Dev Biol Cell and Developmental Biology In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca(2+)) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca(2+) communication on organelle function as well as catabolism and anabolism, particularly in cancer. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC7960657/ /pubmed/33738285 http://dx.doi.org/10.3389/fcell.2021.629522 Text en Copyright © 2021 Ahumada-Castro, Bustos, Silva-Pavez, Puebla-Huerta, Lovy and Cárdenas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ahumada-Castro, Ulises
Bustos, Galdo
Silva-Pavez, Eduardo
Puebla-Huerta, Andrea
Lovy, Alenka
Cárdenas, César
In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title_full In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title_fullStr In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title_full_unstemmed In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title_short In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes
title_sort in the right place at the right time: regulation of cell metabolism by ip3r-mediated inter-organelle ca(2+) fluxes
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960657/
https://www.ncbi.nlm.nih.gov/pubmed/33738285
http://dx.doi.org/10.3389/fcell.2021.629522
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