The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro

The glaucoma-associated E50K mutation in optineurin (OPTN) is known to affect autophagy and cause the apoptosis of retinal ganglion cells (RGCs), but the pathogenic mechanism remains unclear. In this study, we investigated whether the OPTN (E50K) mutation caused TDP-43 aggregation by disrupting auto...

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Detalles Bibliográficos
Autores principales: Zhang, Shiqi, Shao, Zhengbo, Liu, Xinna, Hou, Mingying, Cheng, Fang, Lei, Dawei, Yuan, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960725/
https://www.ncbi.nlm.nih.gov/pubmed/33723228
http://dx.doi.org/10.1038/s41420-021-00432-0

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