Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy

BACKGROUND: Triple negative breast cancers (TNBC) have poor prognoses despite aggressive treatment with cytotoxic chemotherapy. Cancer-associated fibroblasts (CAFs) are prominent in tumour stroma. Our hypothesis was that CAFs modulate chemotherapy sensitivity. METHODS: TNBC cells and breast fibrobla...

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Detalles Bibliográficos
Autores principales: Broad, Robyn V., Jones, Stacey J., Teske, Melina C., Wastall, Laura M., Hanby, Andrew M., Thorne, James L., Hughes, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960738/
https://www.ncbi.nlm.nih.gov/pubmed/33398063
http://dx.doi.org/10.1038/s41416-020-01226-4

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