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The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples

OBJECTIVE: The purpose of this study was to test the hypothesis that a significant temporal relationship exists between asthma and attention deficit hyperactivity disorder (ADHD). METHODS: The population dataset consisted of 95,846,511 physician diagnoses for 768,460 (46% male) individuals spanning...

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Autores principales: Chai, Pang Hua, Chang, Sam, Cawthorpe, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960750/
https://www.ncbi.nlm.nih.gov/pubmed/33601870
http://dx.doi.org/10.30773/pi.2020.0349
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author Chai, Pang Hua
Chang, Sam
Cawthorpe, David
author_facet Chai, Pang Hua
Chang, Sam
Cawthorpe, David
author_sort Chai, Pang Hua
collection PubMed
description OBJECTIVE: The purpose of this study was to test the hypothesis that a significant temporal relationship exists between asthma and attention deficit hyperactivity disorder (ADHD). METHODS: The population dataset consisted of 95,846,511 physician diagnoses for 768,460 (46% male) individuals spanning 1993–2010. Four groups were labeled as having neither Asthma nor ADHD, Asthma only, ADHD only, or both Asthma and ADHD and formed the basis of calculating the odds ratios for each sex describing the association of Asthma and ADHD by age, and, in addition, a prospective sample age (<5 years) between 1993 and 1996 was utilized to evaluate the temporal association between Asthma and ADHD. RESULTS: There was a significant relationship between ADHD and Asthma within the age strata of the sample, one from the cohort and two from the whole sample. When both ADHD and Asthma were diagnosed in the same patients, the age was younger in both cross-sectional and prospective cohort samples. ADHD arose significantly more often after Asthma in the cross-sectional samples stratified on age and in the prospective cohort sample. CONCLUSION: The results are consistent with previous literature where ADHD has been linked to allergic diseases, such as asthma.
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spelling pubmed-79607502021-03-24 The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples Chai, Pang Hua Chang, Sam Cawthorpe, David Psychiatry Investig Original Article OBJECTIVE: The purpose of this study was to test the hypothesis that a significant temporal relationship exists between asthma and attention deficit hyperactivity disorder (ADHD). METHODS: The population dataset consisted of 95,846,511 physician diagnoses for 768,460 (46% male) individuals spanning 1993–2010. Four groups were labeled as having neither Asthma nor ADHD, Asthma only, ADHD only, or both Asthma and ADHD and formed the basis of calculating the odds ratios for each sex describing the association of Asthma and ADHD by age, and, in addition, a prospective sample age (<5 years) between 1993 and 1996 was utilized to evaluate the temporal association between Asthma and ADHD. RESULTS: There was a significant relationship between ADHD and Asthma within the age strata of the sample, one from the cohort and two from the whole sample. When both ADHD and Asthma were diagnosed in the same patients, the age was younger in both cross-sectional and prospective cohort samples. ADHD arose significantly more often after Asthma in the cross-sectional samples stratified on age and in the prospective cohort sample. CONCLUSION: The results are consistent with previous literature where ADHD has been linked to allergic diseases, such as asthma. Korean Neuropsychiatric Association 2021-02 2021-02-22 /pmc/articles/PMC7960750/ /pubmed/33601870 http://dx.doi.org/10.30773/pi.2020.0349 Text en Copyright © 2021 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chai, Pang Hua
Chang, Sam
Cawthorpe, David
The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title_full The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title_fullStr The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title_full_unstemmed The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title_short The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples
title_sort temporal hyper-morbidity of asthma and attention deficit disorder: implications for interpretation based on comparison of prospective and cross-sectional population samples
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960750/
https://www.ncbi.nlm.nih.gov/pubmed/33601870
http://dx.doi.org/10.30773/pi.2020.0349
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