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Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?

Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formatio...

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Autores principales: Hernández-Barranco, Alberto, Nogués, Laura, Peinado, Héctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960773/
https://www.ncbi.nlm.nih.gov/pubmed/33738282
http://dx.doi.org/10.3389/fcell.2021.625221
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author Hernández-Barranco, Alberto
Nogués, Laura
Peinado, Héctor
author_facet Hernández-Barranco, Alberto
Nogués, Laura
Peinado, Héctor
author_sort Hernández-Barranco, Alberto
collection PubMed
description Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as “sleepy niches”). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring.
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spelling pubmed-79607732021-03-17 Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? Hernández-Barranco, Alberto Nogués, Laura Peinado, Héctor Front Cell Dev Biol Cell and Developmental Biology Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as “sleepy niches”). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC7960773/ /pubmed/33738282 http://dx.doi.org/10.3389/fcell.2021.625221 Text en Copyright © 2021 Hernández-Barranco, Nogués and Peinado. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hernández-Barranco, Alberto
Nogués, Laura
Peinado, Héctor
Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title_full Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title_fullStr Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title_full_unstemmed Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title_short Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
title_sort could extracellular vesicles contribute to generation or awakening of “sleepy” metastatic niches?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960773/
https://www.ncbi.nlm.nih.gov/pubmed/33738282
http://dx.doi.org/10.3389/fcell.2021.625221
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