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Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity

Brain gliomas require a deep knowledge of their effects on brain connectivity. Understanding the complex relationship between tumor and functional brain is the preliminary and fundamental step for the subsequent surgery. The extent of resection (EOR) is an independent variable of surgical effectiven...

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Autores principales: Giammalva, Giuseppe Roberto, Brunasso, Lara, Costanzo, Roberta, Paolini, Federica, Umana, Giuseppe Emmanuele, Scalia, Gianluca, Gagliardo, Cesare, Gerardi, Rosa Maria, Basile, Luigi, Graziano, Francesca, Gulì, Carlo, Messina, Domenico, Pino, Maria Angela, Feraco, Paola, Tumbiolo, Silvana, Midiri, Massimo, Iacopino, Domenico Gerardo, Maugeri, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960910/
https://www.ncbi.nlm.nih.gov/pubmed/33738262
http://dx.doi.org/10.3389/fonc.2021.645854
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author Giammalva, Giuseppe Roberto
Brunasso, Lara
Costanzo, Roberta
Paolini, Federica
Umana, Giuseppe Emmanuele
Scalia, Gianluca
Gagliardo, Cesare
Gerardi, Rosa Maria
Basile, Luigi
Graziano, Francesca
Gulì, Carlo
Messina, Domenico
Pino, Maria Angela
Feraco, Paola
Tumbiolo, Silvana
Midiri, Massimo
Iacopino, Domenico Gerardo
Maugeri, Rosario
author_facet Giammalva, Giuseppe Roberto
Brunasso, Lara
Costanzo, Roberta
Paolini, Federica
Umana, Giuseppe Emmanuele
Scalia, Gianluca
Gagliardo, Cesare
Gerardi, Rosa Maria
Basile, Luigi
Graziano, Francesca
Gulì, Carlo
Messina, Domenico
Pino, Maria Angela
Feraco, Paola
Tumbiolo, Silvana
Midiri, Massimo
Iacopino, Domenico Gerardo
Maugeri, Rosario
author_sort Giammalva, Giuseppe Roberto
collection PubMed
description Brain gliomas require a deep knowledge of their effects on brain connectivity. Understanding the complex relationship between tumor and functional brain is the preliminary and fundamental step for the subsequent surgery. The extent of resection (EOR) is an independent variable of surgical effectiveness and it correlates with the overall survival. Until now, great efforts have been made to achieve gross total resection (GTR) as the standard of care of brain tumor patients. However, high and low-grade gliomas have an infiltrative behavior and peritumoral white matter is often infiltrated by tumoral cells. According to these evidences, many efforts have been made to push the boundary of the resection beyond the contrast-enhanced lesion core on T1w MRI, in the so called supratotal resection (SpTR). SpTR is aimed to maximize the extent of resection and thus the overall survival. SpTR of primary brain tumors is a feasible technique and its safety is improved by intraoperative neuromonitoring and advanced neuroimaging. Only transient cognitive impairments have been reported in SpTR patients compared to GTR patients. Moreover, SpTR is related to a longer overall and progression-free survival along with preserving neuro-cognitive functions and quality of life.
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spelling pubmed-79609102021-03-17 Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity Giammalva, Giuseppe Roberto Brunasso, Lara Costanzo, Roberta Paolini, Federica Umana, Giuseppe Emmanuele Scalia, Gianluca Gagliardo, Cesare Gerardi, Rosa Maria Basile, Luigi Graziano, Francesca Gulì, Carlo Messina, Domenico Pino, Maria Angela Feraco, Paola Tumbiolo, Silvana Midiri, Massimo Iacopino, Domenico Gerardo Maugeri, Rosario Front Oncol Oncology Brain gliomas require a deep knowledge of their effects on brain connectivity. Understanding the complex relationship between tumor and functional brain is the preliminary and fundamental step for the subsequent surgery. The extent of resection (EOR) is an independent variable of surgical effectiveness and it correlates with the overall survival. Until now, great efforts have been made to achieve gross total resection (GTR) as the standard of care of brain tumor patients. However, high and low-grade gliomas have an infiltrative behavior and peritumoral white matter is often infiltrated by tumoral cells. According to these evidences, many efforts have been made to push the boundary of the resection beyond the contrast-enhanced lesion core on T1w MRI, in the so called supratotal resection (SpTR). SpTR is aimed to maximize the extent of resection and thus the overall survival. SpTR of primary brain tumors is a feasible technique and its safety is improved by intraoperative neuromonitoring and advanced neuroimaging. Only transient cognitive impairments have been reported in SpTR patients compared to GTR patients. Moreover, SpTR is related to a longer overall and progression-free survival along with preserving neuro-cognitive functions and quality of life. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC7960910/ /pubmed/33738262 http://dx.doi.org/10.3389/fonc.2021.645854 Text en Copyright © 2021 Giammalva, Brunasso, Costanzo, Paolini, Umana, Scalia, Gagliardo, Gerardi, Basile, Graziano, Gulì, Messina, Pino, Feraco, Tumbiolo, Midiri, Iacopino and Maugeri http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Giammalva, Giuseppe Roberto
Brunasso, Lara
Costanzo, Roberta
Paolini, Federica
Umana, Giuseppe Emmanuele
Scalia, Gianluca
Gagliardo, Cesare
Gerardi, Rosa Maria
Basile, Luigi
Graziano, Francesca
Gulì, Carlo
Messina, Domenico
Pino, Maria Angela
Feraco, Paola
Tumbiolo, Silvana
Midiri, Massimo
Iacopino, Domenico Gerardo
Maugeri, Rosario
Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title_full Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title_fullStr Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title_full_unstemmed Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title_short Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
title_sort brain mapping-aided supratotal resection (sptr) of brain tumors: the role of brain connectivity
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960910/
https://www.ncbi.nlm.nih.gov/pubmed/33738262
http://dx.doi.org/10.3389/fonc.2021.645854
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