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The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia

“Neural inertia” is the brain’s tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed across very different species, from invertebrates to mammals. However, th...

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Autores principales: Luppi, Andrea I., Spindler, Lennart R. B., Menon, David K., Stamatakis, Emmanuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960927/
https://www.ncbi.nlm.nih.gov/pubmed/33737863
http://dx.doi.org/10.3389/fnins.2021.643871
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author Luppi, Andrea I.
Spindler, Lennart R. B.
Menon, David K.
Stamatakis, Emmanuel A.
author_facet Luppi, Andrea I.
Spindler, Lennart R. B.
Menon, David K.
Stamatakis, Emmanuel A.
author_sort Luppi, Andrea I.
collection PubMed
description “Neural inertia” is the brain’s tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed across very different species, from invertebrates to mammals. However, the brain is also subject to another form of inertia, familiar to most people: sleep inertia, the feeling of grogginess, confusion and impaired performance that typically follows awakening. Here, we propose a novel account of neural inertia, as the result of sleep inertia taking place after the artificial sleep induced by anaesthetics. We argue that the orexinergic and noradrenergic systems may be key mechanisms for the control of these transition states, with the orexinergic system exerting a stabilising effect through the noradrenergic system. This effect may be reflected at the macroscale in terms of altered functional anticorrelations between default mode and executive control networks of the human brain. The hypothesised link between neural inertia and sleep inertia could explain why different anaesthetic drugs induce different levels of neural inertia, and why elderly individuals and narcoleptic patients are more susceptible to neural inertia. This novel hypothesis also enables us to generate several empirically testable predictions at both the behavioural and neural levels, with potential implications for clinical practice.
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spelling pubmed-79609272021-03-17 The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia Luppi, Andrea I. Spindler, Lennart R. B. Menon, David K. Stamatakis, Emmanuel A. Front Neurosci Neuroscience “Neural inertia” is the brain’s tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed across very different species, from invertebrates to mammals. However, the brain is also subject to another form of inertia, familiar to most people: sleep inertia, the feeling of grogginess, confusion and impaired performance that typically follows awakening. Here, we propose a novel account of neural inertia, as the result of sleep inertia taking place after the artificial sleep induced by anaesthetics. We argue that the orexinergic and noradrenergic systems may be key mechanisms for the control of these transition states, with the orexinergic system exerting a stabilising effect through the noradrenergic system. This effect may be reflected at the macroscale in terms of altered functional anticorrelations between default mode and executive control networks of the human brain. The hypothesised link between neural inertia and sleep inertia could explain why different anaesthetic drugs induce different levels of neural inertia, and why elderly individuals and narcoleptic patients are more susceptible to neural inertia. This novel hypothesis also enables us to generate several empirically testable predictions at both the behavioural and neural levels, with potential implications for clinical practice. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC7960927/ /pubmed/33737863 http://dx.doi.org/10.3389/fnins.2021.643871 Text en Copyright © 2021 Luppi, Spindler, Menon and Stamatakis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Luppi, Andrea I.
Spindler, Lennart R. B.
Menon, David K.
Stamatakis, Emmanuel A.
The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title_full The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title_fullStr The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title_full_unstemmed The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title_short The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
title_sort inert brain: explaining neural inertia as post-anaesthetic sleep inertia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960927/
https://www.ncbi.nlm.nih.gov/pubmed/33737863
http://dx.doi.org/10.3389/fnins.2021.643871
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