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Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives
Nanocarriers have emerged as a promising cancer drug delivery strategy. Multi-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful chemotherapy. Vitamin E derivatives have many essential functions for drug delivery applic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960945/ https://www.ncbi.nlm.nih.gov/pubmed/33778185 http://dx.doi.org/10.1016/j.bioactmat.2021.02.028 |
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author | Chen, Xiaotong Gu, Junxiang Sun, Le Li, Wenya Guo, Lili Gu, Zhiyang Wang, Litong Zhang, Yan Zhang, Wangwang Han, Baoqin Chang, Jing |
author_facet | Chen, Xiaotong Gu, Junxiang Sun, Le Li, Wenya Guo, Lili Gu, Zhiyang Wang, Litong Zhang, Yan Zhang, Wangwang Han, Baoqin Chang, Jing |
author_sort | Chen, Xiaotong |
collection | PubMed |
description | Nanocarriers have emerged as a promising cancer drug delivery strategy. Multi-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful chemotherapy. Vitamin E derivatives have many essential functions for drug delivery applications, such as biological components that are hydrophobic, stable, water-soluble enhancing compounds, and anticancer activity. In addition, vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P glycoproteins. Here, we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system (O-CMCTS-VES). The synthesized polymers were characterized by Fourier Transform IR, and (1)H NMR spectra. The mean sizes of O-CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 nm. The drug loading contents were 6.1%, 13.0% and 10.6% with the weight ratio of DOX to O-CMCTS-VES corresponding 1:10, 2:10 and 3:10, and the corresponding EEs were 64.3%, 74.5% and 39.7%. Cytotoxicity test, hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in vivo. Drug release experiments implied good pH sensitivity and sustained-release effect. The DOX/O-CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%. In the in vivo study by using H22 cells implanted Balb/C mice, DOX/O-CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%. The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors. |
format | Online Article Text |
id | pubmed-7960945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79609452021-03-25 Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives Chen, Xiaotong Gu, Junxiang Sun, Le Li, Wenya Guo, Lili Gu, Zhiyang Wang, Litong Zhang, Yan Zhang, Wangwang Han, Baoqin Chang, Jing Bioact Mater Article Nanocarriers have emerged as a promising cancer drug delivery strategy. Multi-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful chemotherapy. Vitamin E derivatives have many essential functions for drug delivery applications, such as biological components that are hydrophobic, stable, water-soluble enhancing compounds, and anticancer activity. In addition, vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P glycoproteins. Here, we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system (O-CMCTS-VES). The synthesized polymers were characterized by Fourier Transform IR, and (1)H NMR spectra. The mean sizes of O-CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 nm. The drug loading contents were 6.1%, 13.0% and 10.6% with the weight ratio of DOX to O-CMCTS-VES corresponding 1:10, 2:10 and 3:10, and the corresponding EEs were 64.3%, 74.5% and 39.7%. Cytotoxicity test, hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in vivo. Drug release experiments implied good pH sensitivity and sustained-release effect. The DOX/O-CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%. In the in vivo study by using H22 cells implanted Balb/C mice, DOX/O-CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%. The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors. KeAi Publishing 2021-03-09 /pmc/articles/PMC7960945/ /pubmed/33778185 http://dx.doi.org/10.1016/j.bioactmat.2021.02.028 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Chen, Xiaotong Gu, Junxiang Sun, Le Li, Wenya Guo, Lili Gu, Zhiyang Wang, Litong Zhang, Yan Zhang, Wangwang Han, Baoqin Chang, Jing Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title_full | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title_fullStr | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title_full_unstemmed | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title_short | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives |
title_sort | efficient drug delivery and anticancer effect of micelles based on vitamin e succinate and chitosan derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960945/ https://www.ncbi.nlm.nih.gov/pubmed/33778185 http://dx.doi.org/10.1016/j.bioactmat.2021.02.028 |
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