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Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial
BACKGROUND: Patients with refractory colorectal (CRC) cancer have few treatment options. This trial tests the combination of metformin and irinotecan in this setting. METHODS: A phase 2 single-arm trial was conducted, patients received metformin 2500 mg orally a day plus irinotecan 125 mg/m(2) intra...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961008/ https://www.ncbi.nlm.nih.gov/pubmed/33398062 http://dx.doi.org/10.1038/s41416-020-01208-6 |