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Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial

BACKGROUND: Patients with refractory colorectal (CRC) cancer have few treatment options. This trial tests the combination of metformin and irinotecan in this setting. METHODS: A phase 2 single-arm trial was conducted, patients received metformin 2500 mg orally a day plus irinotecan 125 mg/m(2) intra...

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Detalles Bibliográficos
Autores principales:	Bragagnoli, Arinilda Campos, Araujo, Raphael L. C., Ferraz, Mauricio Wagner, dos Santos, Lucas Vieira, Abdalla, Kathia Cristina, Comar, Fabiana, Santos, Florinda Almeida, Oliveira, Marco Antonio, Carvalheira, José Barreto Campello, Cárcano, Flávio Mavigner, da Silveira Nogueira Lima, João Paulo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961008/ https://www.ncbi.nlm.nih.gov/pubmed/33398062 http://dx.doi.org/10.1038/s41416-020-01208-6

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