Cargando…

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimniak, Melissa, Kirschner, Luisa, Hilpert, Helen, Geiger, Nina, Danov, Olga, Oberwinkler, Heike, Steinke, Maria, Sewald, Katherina, Seibel, Jürgen, Bodem, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961020/ https://www.ncbi.nlm.nih.gov/pubmed/33723270 http://dx.doi.org/10.1038/s41598-021-85049-0

Ejemplares similares

Acetylsalicylic Acid and Salicylic Acid Inhibit SARS-CoV-2 Replication in Precision-Cut Lung Slices
por: Geiger, Nina, et al.
Publicado: (2022)

Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine
por: Kobayashi, Katsunori, et al.
Publicado: (2011)

Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
por: Panlilio, Jennifer M., et al.
Publicado: (2016)

Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific
por: Diesendorf, Viktoria, et al.
Publicado: (2023)

Effects of a Selective Serotonin Reuptake Inhibitor, Fluoxetine, on Counterregulatory Responses to Hypoglycemia in Healthy Individuals
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning
por: Weaver, Samantha R., et al.
Publicado: (2019)

A defined anthocyanin mixture sourced from bilberry and black currant inhibits Measles virus and various herpesviruses
por: Sivarajan, Rinu, et al.
Publicado: (2022)

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Cellular Correlates of Enhanced Anxiety Caused by Acute Treatment with the Selective Serotonin Reuptake Inhibitor Fluoxetine in Rats
por: Ravinder, Shilpa, et al.
Publicado: (2011)

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex
por: Tate, Kinsley, et al.
Publicado: (2021)

Sentiment Analysis of Online Reviews for Selective Serotonin Reuptake Inhibitors and Serotonin–Norepinephrine Reuptake Inhibitors
por: Compagner, Chad, et al.
Publicado: (2021)

Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine
por: Shuto, Takahide, et al.
Publicado: (2018)

A modified protocol for successful miRNA profiling in human precision-cut lung slices (PCLS)
por: Niehof, Monika, et al.
Publicado: (2021)

Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells
por: Chang, Huang-Yu, et al.
Publicado: (2017)

The selective serotonin reuptake inhibitor fluoxetine has direct effects on beta cells, promoting insulin secretion and increasing beta‐cell mass
por: Liu, Bo, et al.
Publicado: (2022)

Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors
por: Geiger, Nina, et al.
Publicado: (2023)

Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine
por: Yang, Huaiyu, et al.
Publicado: (2010)

The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods
por: Xie, Yi, et al.
Publicado: (2019)

Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury
por: Ma, Long, et al.
Publicado: (2021)

Rupintrivir reduces RV-induced T(H)-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo
por: Danov, Olga, et al.
Publicado: (2019)

Clinical pharmacology of serotonin selective reuptake inhibitors /
por: Preskorn, Sheldon
Publicado: (1996)

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia
por: Welsch, Patrick, et al.
Publicado: (2018)

Selective serotonin reuptake inhibitors and Alzheimer’s disease
por: Mdawar, Bernadette, et al.
Publicado: (2019)

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation
por: Ungvari, Zoltan, et al.
Publicado: (2019)

Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine
por: Luong, Thu-Lan T., et al.
Publicado: (2022)

Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI)
por: Takata, Junko, et al.
Publicado: (2019)

RNA isolation from precision-cut lung slices (PCLS) from different species
por: Niehof, Monika, et al.
Publicado: (2017)

Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini(®) Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices
por: Reamon-Buettner, Stella Marie, et al.
Publicado: (2019)

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut
por: Fung, Thomas C., et al.
Publicado: (2019)

Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose
por: Little, Kimberly, et al.
Publicado: (2018)

Effect of Serotonin Reuptake Inhibitors on Pulmonary Hemodynamics in Humans
por: Pleym, Hilde, et al.
Publicado: (2011)

Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis
por: Wozniak, Greta, et al.
Publicado: (2011)

Heart Rate Recovery and Selective Serotonin Reuptake Inhibitors
por: Cerit, Levent
Publicado: (2016)

Selective serotonin reuptake inhibitor-induced galactorrhea with hyperprolactinemia
por: Bhattacharjee, Subir, et al.
Publicado: (2021)

Confounding by Indication in Studies of Selective Serotonin Reuptake Inhibitors
por: Lee, Jimin, et al.
Publicado: (2022)

Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (M(pro))
por: Sayed, Ahmed M., et al.
Publicado: (2023)

Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction
por: Venkatachalam, Ananda Baskaran, et al.
Publicado: (2023)

Safety and Efficacy of Drug Holidays for Women with Sexual Dysfunction Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) Other than Fluoxetine: An Open-Label Randomized Clinical Trial
por: Lalegani, Elham, et al.
Publicado: (2023)

Developmental Exposure to Fluoxetine Modulates the Serotonin System in Hypothalamus
por: Berg, Cecilia, et al.
Publicado: (2013)

Transient Serotonin Syndrome Caused by Concurrent Use of Tramadol and Selective Serotonin Reuptake Inhibitor
por: Shakoor, Muhammad Tariq, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pe2lgm3hb9utsunot2gjq6qk5k