The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1(+) tumour-infiltrating lymphocytes

BACKGROUND: Adoptive immunotherapy with tumour-infiltrating lymphocytes (TIL) may benefit from the use of selective markers, such as PD-1, for tumour-specific T-cell enrichment, and the identification of predictive factors that help identify those patients capable of rendering tumour-reactive TILs....

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Detalles Bibliográficos
Autores principales: Salas-Benito, Diego, Conde, Enrique, Tamayo-Uria, Ibon, Mancheño, Uxua, Elizalde, Edurne, Garcia-Ros, David, Aramendia, Jose M., Muruzabal, Juan C., Alcaide, Julia, Guillen-Grima, Francisco, Minguez, Jose A., Amores-Tirado, Jose, Gonzalez-Martin, Antonio, Sarobe, Pablo, Lasarte, Juan J., Ponz-Sarvise, Mariano, De Andrea, Carlos E., Hervas-Stubbs, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961070/
https://www.ncbi.nlm.nih.gov/pubmed/33402737
http://dx.doi.org/10.1038/s41416-020-01218-4

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