Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease

Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients remains low, demonstrating the necessity for nove...

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Detalles Bibliográficos
Autores principales: Hartmann, Oliver, Reissland, Michaela, Maier, Carina R., Fischer, Thomas, Prieto-Garcia, Cristian, Baluapuri, Apoorva, Schwarz, Jessica, Schmitz, Werner, Garrido-Rodriguez, Martin, Pahor, Nikolett, Davies, Clare C., Bassermann, Florian, Orian, Amir, Wolf, Elmar, Schulze, Almut, Calzado, Marco A., Rosenfeldt, Mathias T., Diefenbacher, Markus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961101/
https://www.ncbi.nlm.nih.gov/pubmed/33738287
http://dx.doi.org/10.3389/fcell.2021.641618

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