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Structural basis of fast- and slow-severing actin–cofilactin boundaries

Members of the ADF/cofilin family of regulatory proteins bind actin filaments cooperatively, locally change actin subunit conformation and orientation, and sever filaments at “boundaries” between bare and cofilin-occupied segments. A cluster of bound cofilin introduces two distinct classes of bounda...

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Detalles Bibliográficos
Autores principales: Hocky, Glen M., Sindelar, Charles V., Cao, Wenxiang, Voth, Gregory A., De La Cruz, Enrique M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961102/
https://www.ncbi.nlm.nih.gov/pubmed/33508320
http://dx.doi.org/10.1016/j.jbc.2021.100337