Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

The Wnt inhibitor Dickkopf-1 (DKK1) is a negative regulator of bone formation and bone mass and is dysregulated in various bone diseases. How DKK1 contributes to postmenopausal osteoporosis, however, remains poorly understood. Here, we show that mice lacking DKK1 in T cells are protected from ovarie...

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Detalles Bibliográficos
Autores principales: Lehmann, Juliane, Thiele, Sylvia, Baschant, Ulrike, Rachner, Tilman D., Niehrs, Christof, Hofbauer, Lorenz C., Rauner, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961106/
https://www.ncbi.nlm.nih.gov/pubmed/33748710
http://dx.doi.org/10.1016/j.isci.2021.102224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961106/
https://www.ncbi.nlm.nih.gov/pubmed/33748710
http://dx.doi.org/10.1016/j.isci.2021.102224

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