Cargando…
Platelet Microparticle Controversial Role in Cancer
Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961228/ https://www.ncbi.nlm.nih.gov/pubmed/33747851 http://dx.doi.org/10.34172/apb.2021.005 |
_version_ | 1783665213858381824 |
---|---|
author | Nazari, Mahnaz Javandoost, Ehsan Talebi, Mehdi Movassaghpour, Aliakbar Soleimani, Masoud |
author_facet | Nazari, Mahnaz Javandoost, Ehsan Talebi, Mehdi Movassaghpour, Aliakbar Soleimani, Masoud |
author_sort | Nazari, Mahnaz |
collection | PubMed |
description | Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many of these functions could be deemed as a cornerstone for future considerations of PMPs usage in cancer targeted therapy. This review discusses what is currently known about PMPs and provides insights for new and possible research directions for further grasping the intricate interplay between PMPs and cancer. |
format | Online Article Text |
id | pubmed-7961228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-79612282021-03-19 Platelet Microparticle Controversial Role in Cancer Nazari, Mahnaz Javandoost, Ehsan Talebi, Mehdi Movassaghpour, Aliakbar Soleimani, Masoud Adv Pharm Bull Review Article Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many of these functions could be deemed as a cornerstone for future considerations of PMPs usage in cancer targeted therapy. This review discusses what is currently known about PMPs and provides insights for new and possible research directions for further grasping the intricate interplay between PMPs and cancer. Tabriz University of Medical Sciences 2021-01 2020-11-07 /pmc/articles/PMC7961228/ /pubmed/33747851 http://dx.doi.org/10.34172/apb.2021.005 Text en © 2021 The Authors. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers. |
spellingShingle | Review Article Nazari, Mahnaz Javandoost, Ehsan Talebi, Mehdi Movassaghpour, Aliakbar Soleimani, Masoud Platelet Microparticle Controversial Role in Cancer |
title | Platelet Microparticle Controversial Role in Cancer |
title_full | Platelet Microparticle Controversial Role in Cancer |
title_fullStr | Platelet Microparticle Controversial Role in Cancer |
title_full_unstemmed | Platelet Microparticle Controversial Role in Cancer |
title_short | Platelet Microparticle Controversial Role in Cancer |
title_sort | platelet microparticle controversial role in cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961228/ https://www.ncbi.nlm.nih.gov/pubmed/33747851 http://dx.doi.org/10.34172/apb.2021.005 |
work_keys_str_mv | AT nazarimahnaz plateletmicroparticlecontroversialroleincancer AT javandoostehsan plateletmicroparticlecontroversialroleincancer AT talebimehdi plateletmicroparticlecontroversialroleincancer AT movassaghpouraliakbar plateletmicroparticlecontroversialroleincancer AT soleimanimasoud plateletmicroparticlecontroversialroleincancer |