Enantioselective Synthesis of a New Non-Natural Gabosine

The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene’s biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also a...

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Autores principales: Colobbio, Maximiliano, Pandolfi, Enrique, Schapiro, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961443/
https://www.ncbi.nlm.nih.gov/pubmed/33800731
http://dx.doi.org/10.3390/molecules26051423
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author Colobbio, Maximiliano
Pandolfi, Enrique
Schapiro, Valeria
author_facet Colobbio, Maximiliano
Pandolfi, Enrique
Schapiro, Valeria
author_sort Colobbio, Maximiliano
collection PubMed
description The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene’s biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also accomplished.
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spelling pubmed-79614432021-03-17 Enantioselective Synthesis of a New Non-Natural Gabosine Colobbio, Maximiliano Pandolfi, Enrique Schapiro, Valeria Molecules Article The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene’s biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also accomplished. MDPI 2021-03-06 /pmc/articles/PMC7961443/ /pubmed/33800731 http://dx.doi.org/10.3390/molecules26051423 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colobbio, Maximiliano
Pandolfi, Enrique
Schapiro, Valeria
Enantioselective Synthesis of a New Non-Natural Gabosine
title Enantioselective Synthesis of a New Non-Natural Gabosine
title_full Enantioselective Synthesis of a New Non-Natural Gabosine
title_fullStr Enantioselective Synthesis of a New Non-Natural Gabosine
title_full_unstemmed Enantioselective Synthesis of a New Non-Natural Gabosine
title_short Enantioselective Synthesis of a New Non-Natural Gabosine
title_sort enantioselective synthesis of a new non-natural gabosine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961443/
https://www.ncbi.nlm.nih.gov/pubmed/33800731
http://dx.doi.org/10.3390/molecules26051423
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AT pandolfienrique enantioselectivesynthesisofanewnonnaturalgabosine
AT schapirovaleria enantioselectivesynthesisofanewnonnaturalgabosine

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