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Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-base...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961522/ https://www.ncbi.nlm.nih.gov/pubmed/33807710 http://dx.doi.org/10.3390/jcm10051082 |
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author | Montoya-García, Maria-José Giner, Mercè Marcos, Rodrigo García-Romero, David Olmo-Montes, Francisco-Jesús Miranda, Mª José Hernández-Cruz, Blanca Colmenero, Miguel-Angel Vázquez-Gámez, Mª Angeles |
author_facet | Montoya-García, Maria-José Giner, Mercè Marcos, Rodrigo García-Romero, David Olmo-Montes, Francisco-Jesús Miranda, Mª José Hernández-Cruz, Blanca Colmenero, Miguel-Angel Vázquez-Gámez, Mª Angeles |
author_sort | Montoya-García, Maria-José |
collection | PubMed |
description | Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment. |
format | Online Article Text |
id | pubmed-7961522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79615222021-03-17 Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study Montoya-García, Maria-José Giner, Mercè Marcos, Rodrigo García-Romero, David Olmo-Montes, Francisco-Jesús Miranda, Mª José Hernández-Cruz, Blanca Colmenero, Miguel-Angel Vázquez-Gámez, Mª Angeles J Clin Med Article Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment. MDPI 2021-03-05 /pmc/articles/PMC7961522/ /pubmed/33807710 http://dx.doi.org/10.3390/jcm10051082 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Montoya-García, Maria-José Giner, Mercè Marcos, Rodrigo García-Romero, David Olmo-Montes, Francisco-Jesús Miranda, Mª José Hernández-Cruz, Blanca Colmenero, Miguel-Angel Vázquez-Gámez, Mª Angeles Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title | Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title_full | Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title_fullStr | Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title_full_unstemmed | Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title_short | Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study |
title_sort | fragility fractures and imminent fracture risk in the spanish population: a retrospective observational cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961522/ https://www.ncbi.nlm.nih.gov/pubmed/33807710 http://dx.doi.org/10.3390/jcm10051082 |
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