Cargando…

Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study

Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-base...

Descripción completa

Detalles Bibliográficos
Autores principales: Montoya-García, Maria-José, Giner, Mercè, Marcos, Rodrigo, García-Romero, David, Olmo-Montes, Francisco-Jesús, Miranda, Mª José, Hernández-Cruz, Blanca, Colmenero, Miguel-Angel, Vázquez-Gámez, Mª Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961522/
https://www.ncbi.nlm.nih.gov/pubmed/33807710
http://dx.doi.org/10.3390/jcm10051082
_version_ 1783665278742167552
author Montoya-García, Maria-José
Giner, Mercè
Marcos, Rodrigo
García-Romero, David
Olmo-Montes, Francisco-Jesús
Miranda, Mª José
Hernández-Cruz, Blanca
Colmenero, Miguel-Angel
Vázquez-Gámez, Mª Angeles
author_facet Montoya-García, Maria-José
Giner, Mercè
Marcos, Rodrigo
García-Romero, David
Olmo-Montes, Francisco-Jesús
Miranda, Mª José
Hernández-Cruz, Blanca
Colmenero, Miguel-Angel
Vázquez-Gámez, Mª Angeles
author_sort Montoya-García, Maria-José
collection PubMed
description Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment.
format Online
Article
Text
id pubmed-7961522
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79615222021-03-17 Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study Montoya-García, Maria-José Giner, Mercè Marcos, Rodrigo García-Romero, David Olmo-Montes, Francisco-Jesús Miranda, Mª José Hernández-Cruz, Blanca Colmenero, Miguel-Angel Vázquez-Gámez, Mª Angeles J Clin Med Article Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment. MDPI 2021-03-05 /pmc/articles/PMC7961522/ /pubmed/33807710 http://dx.doi.org/10.3390/jcm10051082 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Montoya-García, Maria-José
Giner, Mercè
Marcos, Rodrigo
García-Romero, David
Olmo-Montes, Francisco-Jesús
Miranda, Mª José
Hernández-Cruz, Blanca
Colmenero, Miguel-Angel
Vázquez-Gámez, Mª Angeles
Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title_full Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title_fullStr Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title_full_unstemmed Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title_short Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study
title_sort fragility fractures and imminent fracture risk in the spanish population: a retrospective observational cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961522/
https://www.ncbi.nlm.nih.gov/pubmed/33807710
http://dx.doi.org/10.3390/jcm10051082
work_keys_str_mv AT montoyagarciamariajose fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT ginermerce fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT marcosrodrigo fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT garciaromerodavid fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT olmomontesfranciscojesus fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT mirandamajose fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT hernandezcruzblanca fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT colmeneromiguelangel fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy
AT vazquezgamezmaangeles fragilityfracturesandimminentfractureriskinthespanishpopulationaretrospectiveobservationalcohortstudy