Cargando…

Pancreatic Cancers with High Grade Tumor Budding Exhibit Hallmarks of Diminished Anti-Tumor Immunity

SIMPLE SUMMARY: Pancreatic cancer, in its most common manifestation pancreatic ductal adenocarcinoma (PDAC), is a uniquely lethal disease with very limited treatment options and few prognostic biomarkers. Tumor budding is a proven independent, adverse prognostic factor in many tumor types including...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadozai, Hassan, Acharjee, Animesh, Gruber, Thomas, Gloor, Beat, Karamitopoulou, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961597/ https://www.ncbi.nlm.nih.gov/pubmed/33806316 http://dx.doi.org/10.3390/cancers13051090

Ejemplares similares

Distinct Stromal and Immune Features Collectively Contribute to Long-Term Survival in Pancreatic Cancer
por: Sadozai, Hassan, et al.
Publicado: (2021)

Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)
por: Karamitopoulou, Eva, et al.
Publicado: (2013)

Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma
por: Wartenberg, Martin, et al.
Publicado: (2015)

Role of Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Is Tumor Budding the Missing Link?
por: Karamitopoulou, Eva
Publicado: (2013)

Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer
por: Karamitopoulou, Eva
Publicado: (2013)

Clinical Scenarios Emerging from Combined Immunophenotypic, Molecular and Morphologic Analysis of Pancreatic Cancer: The Good, the Bad and the Ugly Scenario
por: Karamitopoulou, Eva, et al.
Publicado: (2019)

The Tumor Microenvironment of Pancreatic Cancer
por: Karamitopoulou, Eva
Publicado: (2020)

Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study
por: Karamitopoulou, Eva, et al.
Publicado: (2020)

Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer
por: Galván, J A, et al.
Publicado: (2015)

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
por: Galván, José A., et al.
Publicado: (2014)

DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells
por: Ivanovska, Jelena, et al.
Publicado: (2015)

Tumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast
por: Hiratsuka, Miyuki, et al.
Publicado: (2022)

Correction: DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells
por: Ivanovska, Jelena, et al.
Publicado: (2017)

Tumour budding: a promising parameter in colorectal cancer
por: Lugli, A, et al.
Publicado: (2012)

Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction
por: Khan, Saifur R., et al.
Publicado: (2020)

Molecular Pathology of Pancreatic Cancer
por: Karamitopoulou, Eva
Publicado: (2022)

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
por: Renner, Kathrin, et al.
Publicado: (2017)

Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer
por: Sokol, Lena, et al.
Publicado: (2015)

Prognostic significance of intra-tumoral budding in high-grade serous ovarian carcinomas
por: Hachisuga, Toru, et al.
Publicado: (2022)

Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
por: Karamitopoulou, Eva
Publicado: (2019)

Aging hallmarks exhibit organ-specific temporal signatures
por: Schaum, Nicholas, et al.
Publicado: (2020)

High-Grade Tumor Budding Stratifies Early-Stage Cervical Cancer with Recurrence Risk
por: Huang, Bangxing, et al.
Publicado: (2016)

Reappraisal of Grading in Intestinal-Type Sinonasal Adenocarcinoma: Tumor Budding as an Independent Prognostic Parameter
por: Meerwein, Christian M., et al.
Publicado: (2022)

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
por: Zlobec, Inti, et al.
Publicado: (2010)

Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression
por: Walsh, John J., et al.
Publicado: (2021)

Editorial: Tumor microenvironment in cancer hallmarks and therapeutics
por: Luo, Na
Publicado: (2022)

Cancer hallmarks intersect with neuroscience in the tumor microenvironment
por: Hanahan, Douglas, et al.
Publicado: (2023)

Editorial: Hallmark of cancer: tumor promoting inflammation
por: Roncati, Luca, et al.
Publicado: (2023)

New Histoprognostic Factors to Consider for the Staging of Colon Cancers: Tumor Deposits, Invasive Tumor Infiltration and High-Grade Budding
por: Riffet, Marc, et al.
Publicado: (2023)

Tumor budding in gastric cancer
por: Xiao, Shuo-Meng, et al.
Publicado: (2023)

Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma
por: Maibach, Fabienne, et al.
Publicado: (2020)

Tumor acidity: From hallmark of cancer to target of treatment
por: Bogdanov, Alexey, et al.
Publicado: (2022)

Platelets in the tumor microenvironment and their biological effects on cancer hallmarks
por: Chen, Lilan, et al.
Publicado: (2023)

Prognostic Role of High-Grade Tumor Budding in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis with a Focus on Epithelial to Mesenchymal Transition
por: Lawlor, Rita T., et al.
Publicado: (2019)

High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma
por: Luo, Li, et al.
Publicado: (2023)

In Vitro Anti-Tumor and Hypoglycemic Effects of Total Flavonoids from Willow Buds
por: Zhang, Peng, et al.
Publicado: (2023)

Tumor Budding in Upper Gastrointestinal Carcinomas
por: Koelzer, Viktor H., et al.
Publicado: (2014)

Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma
por: XUE, ZHANXIONG, et al.
Publicado: (2016)

Tumor Budding Is an Independent Prognostic Factor in Pancreatic Adenocarcinoma and It Positively Correlates with PD-L1 Expression on Tumor Cells
por: Pęksa, Rafał, et al.
Publicado: (2022)

Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma
por: Zhao, Xianda, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1s8r99kv42qagi6oghu32ujenm