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Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats
Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961647/ https://www.ncbi.nlm.nih.gov/pubmed/33576293 http://dx.doi.org/10.1177/1091581820986073 |
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author | Deshmukh, Narendra S. Gumaste, Shailesh Subah, Silma Bogoda, Nathasha Omal |
author_facet | Deshmukh, Narendra S. Gumaste, Shailesh Subah, Silma Bogoda, Nathasha Omal |
author_sort | Deshmukh, Narendra S. |
collection | PubMed |
description | Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000 mg/kg body weight, according to Organisation for Economic Co-operation and Development Test Guideline No. 414. On gestation day 20, cesarean sections were performed on the dams, followed by examination of their ovaries and uterine contents. The fetuses were further examined for external, visceral, and skeletal abnormalities. Palmitoylethanolamide did not cause any alterations at any of the given dosages in the measured maternal parameters of systemic toxicity (body weight, food consumption, survival, thyroid functions, organ weight, histopathology), reproductive toxicity (preimplantation and postimplantation losses, uterus weight, number of live/dead implants and early/late resorptions, litter size and weights, number of fetuses, their sex ratio), and fetal external, visceral, or skeletal observations. Any alterations that were recorded were “normal variations” or “minor anomalies,” which were unrelated to treatment with PEA. Under the condition of this prenatal study, the no-observed-adverse-effect level of PEA for maternal toxicity, embryotoxicity, fetotoxicity, and teratogenicity in rats was found to be >1,000 mg/kg body weight/d. It indicates that PEA is well tolerated by and is safe to pregnant rats even at a high dose of 1,000 mg/kg body weight/d, equivalent to a human dose of greater than 9.7 g/d. This prenatal developmental toxicity study contributes greatly in building a robust safety profile for PEA. |
format | Online Article Text |
id | pubmed-7961647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79616472021-03-30 Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats Deshmukh, Narendra S. Gumaste, Shailesh Subah, Silma Bogoda, Nathasha Omal Int J Toxicol Original Articles Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000 mg/kg body weight, according to Organisation for Economic Co-operation and Development Test Guideline No. 414. On gestation day 20, cesarean sections were performed on the dams, followed by examination of their ovaries and uterine contents. The fetuses were further examined for external, visceral, and skeletal abnormalities. Palmitoylethanolamide did not cause any alterations at any of the given dosages in the measured maternal parameters of systemic toxicity (body weight, food consumption, survival, thyroid functions, organ weight, histopathology), reproductive toxicity (preimplantation and postimplantation losses, uterus weight, number of live/dead implants and early/late resorptions, litter size and weights, number of fetuses, their sex ratio), and fetal external, visceral, or skeletal observations. Any alterations that were recorded were “normal variations” or “minor anomalies,” which were unrelated to treatment with PEA. Under the condition of this prenatal study, the no-observed-adverse-effect level of PEA for maternal toxicity, embryotoxicity, fetotoxicity, and teratogenicity in rats was found to be >1,000 mg/kg body weight/d. It indicates that PEA is well tolerated by and is safe to pregnant rats even at a high dose of 1,000 mg/kg body weight/d, equivalent to a human dose of greater than 9.7 g/d. This prenatal developmental toxicity study contributes greatly in building a robust safety profile for PEA. SAGE Publications 2021-02-12 2021-03 /pmc/articles/PMC7961647/ /pubmed/33576293 http://dx.doi.org/10.1177/1091581820986073 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Deshmukh, Narendra S. Gumaste, Shailesh Subah, Silma Bogoda, Nathasha Omal Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title | Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title_full | Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title_fullStr | Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title_full_unstemmed | Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title_short | Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats |
title_sort | palmitoylethanolamide: prenatal developmental toxicity study in rats |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961647/ https://www.ncbi.nlm.nih.gov/pubmed/33576293 http://dx.doi.org/10.1177/1091581820986073 |
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