Cargando…

Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities

[Image: see text] Protein and phosphoinositide kinases have been successfully exploited as drug targets in various disease areas, principally in oncology. In malaria, several protein kinases are under investigation as potential drug targets, and an inhibitor of Plasmodium phosphatidylinositol 4-kina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arendse, Lauren B., Wyllie, Susan, Chibale, Kelly, Gilbert, Ian H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961706/ https://www.ncbi.nlm.nih.gov/pubmed/33590753 http://dx.doi.org/10.1021/acsinfecdis.0c00724

Ejemplares similares

Update and elucidation of Plasmodium kinomes: Prioritization of kinases as potential drug targets for malaria
por: Borba, Joyce Villa Verde Bastos, et al.
Publicado: (2022)

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery
por: Okombo, John, et al.
Publicado: (2017)

Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria
por: McNamara, Case W, et al.
Publicado: (2013)

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics
por: Ghidelli-Disse, Sonja, et al.
Publicado: (2014)

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
por: Alam, Asrar
Publicado: (2014)

Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy
por: Sumam de Oliveira, Daffiny, et al.
Publicado: (2021)

MalDA, Accelerating Malaria Drug Discovery
por: Yang, Tuo, et al.
Publicado: (2021)

Anti-trypanosomatid drug discovery: progress and challenges
por: De Rycker, Manu, et al.
Publicado: (2022)

Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart
por: Nassal, Drew, et al.
Publicado: (2020)

New opportunities for kinase drug repurposing and target discovery
por: Knapp, Stefan
Publicado: (2018)

CRIMALDDI: platform technologies and novel anti-malarial drug targets
por: Vial, Henri, et al.
Publicado: (2013)

Tyrosine Kinase Inhibitors for Glioblastoma Multiforme: Challenges and Opportunities for Drug Delivery
por: Brar, Harpinder K., et al.
Publicado: (2022)

Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics
por: Ruscetta, Vanessa M., et al.
Publicado: (2023)

Malaria and Economic Evaluation Methods: Challenges and Opportunities
por: Drake, Tom L., et al.
Publicado: (2017)

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development
por: Biber, Knut, et al.
Publicado: (2019)

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites
por: Zeeman, Anne-Marie, et al.
Publicado: (2016)

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
por: Milne, Rachel, et al.
Publicado: (2022)

Strategies to Combat Multi-Drug Resistance in Tuberculosis
por: Singh, Vinayak, et al.
Publicado: (2021)

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
por: Jones, Deuan C, et al.
Publicado: (2012)

Decorating Nanoparticle Surface for Targeted Drug Delivery: Opportunities and Challenges
por: Shen, Zhiqiang, et al.
Publicado: (2016)

Deployment of ACT antimalarials for treatment of malaria: challenges and opportunities
por: Whitty, Christopher JM, et al.
Publicado: (2008)

Drug-drug cocrystals: Opportunities and challenges
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Plasmodium vivax Sporozoite Challenge in Malaria-Naïve and Semi-Immune Colombian Volunteers
por: Arévalo-Herrera, Myriam, et al.
Publicado: (2014)

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
por: Torrie, Leah S., et al.
Publicado: (2009)

Drug discovery research in Ghana, challenges, current efforts, and the way forward
por: Amewu, Richard Kwamla, et al.
Publicado: (2022)

Plasmodium knowlesi-mediated zoonotic malaria: A challenge for elimination
por: Naik, Durgadas Govind
Publicado: (2020)

Taking on Plasmodium vivax malaria: A timely and important challenge
por: von Seidlein, Lorenz, et al.
Publicado: (2021)

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates
por: Okombo, John, et al.
Publicado: (2018)

Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers
por: Sinxadi, Phumla, et al.
Publicado: (2020)

Current Challenges and Opportunities in Designing Protein–Protein Interaction Targeted Drugs
por: Shin, Woong-Hee, et al.
Publicado: (2020)

Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening
por: Xie, Cuiying, et al.
Publicado: (2023)

Editorial: Drug-ability strategies for potential antimycobacterial candidate: opportunities and challenges
por: Swain, Shasank Sekhar, et al.
Publicado: (2023)

Challenges and opportunities for improving access to approved neonatal drugs and devices
por: Lewis, Tamorah, et al.
Publicado: (2022)

Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery
por: Oleinikov, Andrew V.
Publicado: (2022)

Plasmodium vivax Genetic Diversity in Panama: Challenges for Malaria Elimination in Mesoamerica
por: Santamaría, Ana María, et al.
Publicado: (2021)

The challenges of Plasmodium vivax human malaria infection models for vaccine development
por: Roobsoong, Wanlapa, et al.
Publicado: (2023)

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges
por: Kong, Anna Hau-Yee, et al.
Publicado: (2023)

Pediatric Drug Development: Challenges and Opportunities
por: Spadoni, Cesare
Publicado: (2018)

Anthelmintics for drug repurposing: Opportunities and challenges
por: Alavi, Seyed Ebrahim, et al.
Publicado: (2021)

Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria
por: Koumpoura, Christina L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7ejuntcqoiqejoaquamkgl1jqn