An Intraocular Pressure Measurement Technique Based on Acoustic Radiation Force Using an Ultrasound Transducer: A Feasibility Study

High intraocular pressure (IOP) is one of the major risk factors for glaucoma, and thus accurate IOP measurements should be performed to diagnose and treat glaucoma early. In this study, a novel technique for measuring the IOP based on acoustic radiation force was proposed, and its potential was experimentally demonstrated. The proposed technique uses the acoustic radiation force to generate axial displacement on the ocular surface while simultaneously measuring the degree of deformation. In order to verify that the ocular displacement induced by the acoustic radiation force is related to the IOP, the experiment was conducted by fabricating a 5 MHz single element transducer and gelatin phantoms with different stiffness values. Our experimental results show that there is a close relationship between the ocular displacement by the acoustic radiation force and the IOP obtained by a commercial tonometer. Therefore, the proposed acoustic radiation force technique can be a promising candidate for measuring the IOP.