Cargando…

The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience

Background: Knowledge about the impact of allogeneic hematopoietic stem cell transplantation (alloHSCT) on renal function in children is still limited. Objectives: The aim of the study was to evaluate kidney function in children undergoing alloHSCT, with special focus on differences between patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Musiał, Kinga, Kałwak, Krzysztof, Zwolińska, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961834/
https://www.ncbi.nlm.nih.gov/pubmed/33799964
http://dx.doi.org/10.3390/jcm10051113
_version_ 1783665347103031296
author Musiał, Kinga
Kałwak, Krzysztof
Zwolińska, Danuta
author_facet Musiał, Kinga
Kałwak, Krzysztof
Zwolińska, Danuta
author_sort Musiał, Kinga
collection PubMed
description Background: Knowledge about the impact of allogeneic hematopoietic stem cell transplantation (alloHSCT) on renal function in children is still limited. Objectives: The aim of the study was to evaluate kidney function in children undergoing alloHSCT, with special focus on differences between patients transplanted due to oncological and non-oncological indications. Materials and Methods: The data of 135 children undergoing alloHSCT were analyzed retrospectively. The serum creatinine and estimated glomerular filtration rate (eGFR) values were estimated before transplantation at 24 h; 1, 2, 3, 4 and 8 weeks; and 3 and 6 months after alloHSCT. Then, acute kidney injury (AKI) incidence was assessed. Results: Oncological children presented with higher eGFR values and more frequent hyperfiltration rates than non-oncological children before alloHSCT and until the 4th week after transplantation. The eGFR levels rose significantly after alloHSCT, returned to pre-transplant records after 2–3 weeks, and decreased gradually until the 6th month. AKI incidence was comparable in oncological and non-oncological patients. Conclusions: Children undergoing alloHSCT due to oncological and non-oncological reasons demonstrate the same risk of AKI, but oncological patients may be more prone to sustained renal injury. Serum creatinine and eGFR seem to be insufficient tools to assess kidney function in the early post-alloHSCT period, when hyperfiltration prevails, yet they reveal significant differences in long-term observation.
format Online
Article
Text
id pubmed-7961834
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79618342021-03-17 The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience Musiał, Kinga Kałwak, Krzysztof Zwolińska, Danuta J Clin Med Article Background: Knowledge about the impact of allogeneic hematopoietic stem cell transplantation (alloHSCT) on renal function in children is still limited. Objectives: The aim of the study was to evaluate kidney function in children undergoing alloHSCT, with special focus on differences between patients transplanted due to oncological and non-oncological indications. Materials and Methods: The data of 135 children undergoing alloHSCT were analyzed retrospectively. The serum creatinine and estimated glomerular filtration rate (eGFR) values were estimated before transplantation at 24 h; 1, 2, 3, 4 and 8 weeks; and 3 and 6 months after alloHSCT. Then, acute kidney injury (AKI) incidence was assessed. Results: Oncological children presented with higher eGFR values and more frequent hyperfiltration rates than non-oncological children before alloHSCT and until the 4th week after transplantation. The eGFR levels rose significantly after alloHSCT, returned to pre-transplant records after 2–3 weeks, and decreased gradually until the 6th month. AKI incidence was comparable in oncological and non-oncological patients. Conclusions: Children undergoing alloHSCT due to oncological and non-oncological reasons demonstrate the same risk of AKI, but oncological patients may be more prone to sustained renal injury. Serum creatinine and eGFR seem to be insufficient tools to assess kidney function in the early post-alloHSCT period, when hyperfiltration prevails, yet they reveal significant differences in long-term observation. MDPI 2021-03-07 /pmc/articles/PMC7961834/ /pubmed/33799964 http://dx.doi.org/10.3390/jcm10051113 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Musiał, Kinga
Kałwak, Krzysztof
Zwolińska, Danuta
The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title_full The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title_fullStr The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title_full_unstemmed The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title_short The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children—A Single Center Experience
title_sort impact of allogeneic hematopoietic stem cell transplantation on kidney function in children—a single center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961834/
https://www.ncbi.nlm.nih.gov/pubmed/33799964
http://dx.doi.org/10.3390/jcm10051113
work_keys_str_mv AT musiałkinga theimpactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience
AT kałwakkrzysztof theimpactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience
AT zwolinskadanuta theimpactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience
AT musiałkinga impactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience
AT kałwakkrzysztof impactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience
AT zwolinskadanuta impactofallogeneichematopoieticstemcelltransplantationonkidneyfunctioninchildrenasinglecenterexperience