NMR-Guided Repositioning of Non-Steroidal Anti-Inflammatory Drugs into Tight Junction Modulators

Bioavailability is a major bottleneck in the clinical application of medium molecular weight therapeutics, including protein and peptide drugs. Paracellular transport of these molecules is hampered by intercellular tight junction (TJ) complexes. Therefore, safe chemical regulators for TJ loosening a...

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Detalles Bibliográficos
Autores principales: Tenno, Takeshi, Kataoka, Kohki, Goda, Natsuko, Hiroaki, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961873/
https://www.ncbi.nlm.nih.gov/pubmed/33806674
http://dx.doi.org/10.3390/ijms22052583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961873/
https://www.ncbi.nlm.nih.gov/pubmed/33806674
http://dx.doi.org/10.3390/ijms22052583

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