Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices

Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devic...

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Autores principales: Tomoda, Bruno Thorihara, Pacheco, Murilo Santos, Abranches, Yasmin Broso, Viganó, Juliane, Perrechil, Fabiana, De Moraes, Mariana Agostini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961930/
https://www.ncbi.nlm.nih.gov/pubmed/33807825
http://dx.doi.org/10.3390/polym13050798
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author Tomoda, Bruno Thorihara
Pacheco, Murilo Santos
Abranches, Yasmin Broso
Viganó, Juliane
Perrechil, Fabiana
De Moraes, Mariana Agostini
author_facet Tomoda, Bruno Thorihara
Pacheco, Murilo Santos
Abranches, Yasmin Broso
Viganó, Juliane
Perrechil, Fabiana
De Moraes, Mariana Agostini
author_sort Tomoda, Bruno Thorihara
collection PubMed
description Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold.
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spelling pubmed-79619302021-03-17 Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices Tomoda, Bruno Thorihara Pacheco, Murilo Santos Abranches, Yasmin Broso Viganó, Juliane Perrechil, Fabiana De Moraes, Mariana Agostini Polymers (Basel) Article Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold. MDPI 2021-03-05 /pmc/articles/PMC7961930/ /pubmed/33807825 http://dx.doi.org/10.3390/polym13050798 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomoda, Bruno Thorihara
Pacheco, Murilo Santos
Abranches, Yasmin Broso
Viganó, Juliane
Perrechil, Fabiana
De Moraes, Mariana Agostini
Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title_full Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title_fullStr Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title_full_unstemmed Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title_short Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices
title_sort assessing the influence of dyes physico-chemical properties on incorporation and release kinetics in silk fibroin matrices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961930/
https://www.ncbi.nlm.nih.gov/pubmed/33807825
http://dx.doi.org/10.3390/polym13050798
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