Cargando…

Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaneto, Hideaki, Kimura, Tomohiko, Obata, Atsushi, Shimoda, Masashi, Kaku, Kohei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962041/ https://www.ncbi.nlm.nih.gov/pubmed/33807522 http://dx.doi.org/10.3390/ijms22052596

Ejemplares similares

Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library
por: Kaneto, Hideaki, et al.
Publicado: (2023)

Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class
por: Kaneto, Hideaki, et al.
Publicado: (2021)

Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus
por: Kaneto, Hideaki, et al.
Publicado: (2022)

Notable Underlying Mechanism for Pancreatic β-Cell Dysfunction and Atherosclerosis: Pleiotropic Roles of Incretin and Insulin Signaling
por: Kaneto, Hideaki, et al.
Publicado: (2020)

Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine
por: Kaneto, Hideaki, et al.
Publicado: (2021)

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism
por: Nakashima, Koji, et al.
Publicado: (2018)

Syndrome of inappropriate secretion of thyroid-stimulating hormone in a subject with galactorrhea and menstrual disorder and undergoing infertility treatment: Case report
por: Kaneto, Hideaki, et al.
Publicado: (2021)

A Male Subject with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency Which Was Diagnosed at 31 Years Old due to Infertility
por: Kaneto, Hideaki, et al.
Publicado: (2023)

Case of iliopsoas abscess that was markedly recovered after percutaneous and surgical drainage in a patient with poorly controlled type 2 diabetes
por: Obata, Atsushi, et al.
Publicado: (2016)

Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study
por: Hirukawa, Hidenori, et al.
Publicado: (2018)

Multiple endocrine neoplasia type 1 with a frameshift mutation in its gene accompanied by a giant cervical lipoma and multiple fatty deposits in the pancreas: case report
por: Fushimi, Yoshiro, et al.
Publicado: (2021)

Idiopathic Bilateral Extraocular Myositis in a Subject With Poorly Controlled Type 2 Diabetes Mellitus: Case Report
por: Tatsumi, Fuminori, et al.
Publicado: (2021)

Amelioration of hypercalcemia by cinacalcet treatment in a subject with relapsing acquired hypocalciuric hypercalcemia: A case report
por: Sanada, Junpei, et al.
Publicado: (2021)

Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
por: Katakura, Yukino, et al.
Publicado: (2021)

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice
por: Obata, Atsushi, et al.
Publicado: (2019)

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules
por: Sanada, Junpei, et al.
Publicado: (2022)

A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time
por: Isobe, Hayato, et al.
Publicado: (2021)

Case report of severe hypoglycemic alcoholic ketoacidosis: A possible pitfall in diagnosis of ketoacidosis
por: Okauchi, Seizo, et al.
Publicado: (2022)

Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better
por: Sanada, Junpei, et al.
Publicado: (2021)

Case Report: Malignant Pheochromocytoma Without Hypertension Accompanied by Increment of Serum VEGF Level and Catecholamine Cardiomyopathy
por: Kaneto, Hideaki, et al.
Publicado: (2021)

Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus
por: Shimoda, Masashi, et al.
Publicado: (2017)

Strawberry milk-like blood in a subject with diabetic lipemia: dramatic change to transparent color after insulin therapy
por: Obata, Atsushi, et al.
Publicado: (2016)

Effect of Tofogliflozin on Body Composition and Glycemic Control in Japanese Subjects with Type 2 Diabetes Mellitus
por: Kamei, Shinji, et al.
Publicado: (2018)

Onset of type 1 diabetes mellitus and heparin‐induced thrombocytopenia in a patient with Basedow's disease and idiopathic thrombocytopenic purpura: Novel combination as autoimmune polyglandular syndrome
por: Kinoshita, Tomoe, et al.
Publicado: (2018)

Advanced breast cancer in a relatively young man with severe obesity and type 2 diabetes mellitus
por: Obata, Atsushi, et al.
Publicado: (2017)

Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
por: Kimura, Tomohiko, et al.
Publicado: (2021)

Association between Grit Scales and adherence to regular hospital visits among Japanese patients with type 2 diabetes: Prospective observational study
por: Nakanishi, Shuhei, et al.
Publicado: (2021)

Human serum albumin: Possible cause of insulin autoimmune syndrome
por: Kamei, Shinji, et al.
Publicado: (2016)

Switching From Daily DPP-4 Inhibitor to Once-Weekly GLP-1 Receptor Activator Dulaglutide Significantly Ameliorates Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Observational Study
por: Sanada, Junpei, et al.
Publicado: (2021)

Vitamin D deficiency osteomalacia triggered by long-term social withdrawal and unbalanced diet in a Japanese middle-aged subject: A case report
por: Iwamoto, Yuichiro, et al.
Publicado: (2022)

Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice
por: Fushimi, Yoshiro, et al.
Publicado: (2021)

Switching from low‐dose thiazide diuretics to sodium–glucose cotransporter 2 inhibitor improves various metabolic parameters without affecting blood pressure in patients with type 2 diabetes and hypertension
por: Kimura, Tomohiko, et al.
Publicado: (2017)

There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study
por: Kinoshita, Tomoe, et al.
Publicado: (2018)

Verification of Kumamoto Declaration 2013 and Glycemic Targets for Elderly Patients with Diabetes in Japan for prevention of diabetic complications: A retrospective longitudinal study using outpatient clinical data
por: Nakanishi, Shuhei, et al.
Publicado: (2018)

Temporal lobe epilepsy associated with GAD autoimmunity
por: Obata, Atsushi, et al.
Publicado: (2016)

Sudden extensive bloody pleural and pericardial effusion in a subject with untreated known hypothyroidism after total thyroidectomy, triggered by pneumonia
por: Iwamoto, Yuichiro, et al.
Publicado: (2022)

Clinical Characteristics of Withdrawal of Basal Insulin Therapy Among Japanese Patients with Type 2 Diabetes: A Multicenter Retrospective Observational Study
por: Nakanishi, Shuhei, et al.
Publicado: (2021)

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients
por: Shimoda, Masashi, et al.
Publicado: (2015)

Case Report: Repeated esophageal obstruction in a patient with type 3C diabetes mellitus
por: Koyama, Katsumasa, et al.
Publicado: (2023)

Incidence of endocrine-related immune-related adverse events in Japanese subjects with various types of cancer
por: Iwamoto, Yuichiro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dle0f36v7ldl6itc4e3o0fm5vf