Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury

BACKGROUND: Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many critically ill patients. Although cell-based therapies have shown promise in experim...

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Detalles Bibliográficos
Autores principales: Florian, Maria, Wang, Jia-Pey, Deng, Yupu, Souza-Moreira, Luciana, Stewart, Duncan J., Mei, Shirley H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962085/
https://www.ncbi.nlm.nih.gov/pubmed/33726829
http://dx.doi.org/10.1186/s13287-021-02245-5

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