The Complex Structure of Protein AaLpxC from Aquifex aeolicus with ACHN-975 Molecule Suggests an Inhibitory Mechanism at Atomic-Level against Gram-Negative Bacteria

New drugs with novel antibacterial targets for Gram-negative bacterial pathogens are desperately needed. The protein LpxC is a vital enzyme for the biosynthesis of lipid A, an outer membrane component of Gram-negative bacterial pathogens. The ACHN-975 molecule has high enzymatic inhibitory capacity...

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Detalles Bibliográficos
Autores principales: Fan, Shuai, Li, Danyang, Yan, Maocai, Feng, Xiao, Lv, Guangxin, Wu, Guangteng, Jin, Yuanyuan, Wang, Yucheng, Yang, Zhaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962117/
https://www.ncbi.nlm.nih.gov/pubmed/33800069
http://dx.doi.org/10.3390/molecules26051451

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