A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer

BACKGROUND: Mismatch repair (MMR)/microsatellite instability (MSI) and tumor mutational burden (TMB) are independent biomarkers that complement each other for predicting immune checkpoint inhibitors (ICIs) efficacy. Here we aim to establish a strategy that integrates MSI and TMB determination for co...

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Detalles Bibliográficos
Autores principales: Xiao, Jian, Li, Wenyun, Huang, Yan, Huang, Mengli, Li, Shanshan, Zhai, Xiaohui, Zhao, Jing, Gao, Chan, Xie, Wenzhuan, Qin, Hao, Cai, Shangli, Bai, Yuezong, Lan, Ping, Zou, Yifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962287/
https://www.ncbi.nlm.nih.gov/pubmed/33726687
http://dx.doi.org/10.1186/s12885-021-07942-1

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