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Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions

OBJECTIVES: Persons with MS (PwMS) often display symptoms of depression and fatigue. Mindfulness-based interventions are known to counteract these symptoms. However, to-date the exact relations between trait mindfulness, depression and fatigue remain to be examined. Fatigue is generally regarded as...

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Autores principales: Sauder, Torsten, Keune, Philipp M., Müller, Roy, Schenk, Thomas, Oschmann, Patrick, Hansen, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962308/
https://www.ncbi.nlm.nih.gov/pubmed/33726702
http://dx.doi.org/10.1186/s12883-021-02120-z
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author Sauder, Torsten
Keune, Philipp M.
Müller, Roy
Schenk, Thomas
Oschmann, Patrick
Hansen, Sascha
author_facet Sauder, Torsten
Keune, Philipp M.
Müller, Roy
Schenk, Thomas
Oschmann, Patrick
Hansen, Sascha
author_sort Sauder, Torsten
collection PubMed
description OBJECTIVES: Persons with MS (PwMS) often display symptoms of depression and fatigue. Mindfulness-based interventions are known to counteract these symptoms. However, to-date the exact relations between trait mindfulness, depression and fatigue remain to be examined. Fatigue is generally regarded as a symptom immanent to the disease and as a direct neurobiological consequence of increased cytokine levels and cortical atrophy. In depression on the other hand, psychosocial factors in the context of adaptation difficulties are probably of higher relevance. Hence, one may argue that mindfulness, as a trait that promotes successful adaption, may show a strong negative association with depression and a relatively minor negative association with fatigue in PwMS. METHODS: In the current study, the association between self-reported trait mindfulness, fatigue and depression was examined in a sample of 69 PwMS. RESULTS: Trait mindfulness showed highly significant negative correlations with both, depression and fatigue. Mediation analyses however, revealed that depression mediated the relation between mindfulness and fatigue. CONCLUSION: It may be concluded that in PwMS, trait mindfulness shows a genuine negative association with depression, but that it is only secondarily associated with fatigue. Implications for mindfulness-based interventions in MS are discussed. Based on the results of the current study, it may be feasible to promote the acceptance of default fatigue symptoms, instead of an actual reduction of fatigue symptoms.
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spelling pubmed-79623082021-03-16 Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions Sauder, Torsten Keune, Philipp M. Müller, Roy Schenk, Thomas Oschmann, Patrick Hansen, Sascha BMC Neurol Research Article OBJECTIVES: Persons with MS (PwMS) often display symptoms of depression and fatigue. Mindfulness-based interventions are known to counteract these symptoms. However, to-date the exact relations between trait mindfulness, depression and fatigue remain to be examined. Fatigue is generally regarded as a symptom immanent to the disease and as a direct neurobiological consequence of increased cytokine levels and cortical atrophy. In depression on the other hand, psychosocial factors in the context of adaptation difficulties are probably of higher relevance. Hence, one may argue that mindfulness, as a trait that promotes successful adaption, may show a strong negative association with depression and a relatively minor negative association with fatigue in PwMS. METHODS: In the current study, the association between self-reported trait mindfulness, fatigue and depression was examined in a sample of 69 PwMS. RESULTS: Trait mindfulness showed highly significant negative correlations with both, depression and fatigue. Mediation analyses however, revealed that depression mediated the relation between mindfulness and fatigue. CONCLUSION: It may be concluded that in PwMS, trait mindfulness shows a genuine negative association with depression, but that it is only secondarily associated with fatigue. Implications for mindfulness-based interventions in MS are discussed. Based on the results of the current study, it may be feasible to promote the acceptance of default fatigue symptoms, instead of an actual reduction of fatigue symptoms. BioMed Central 2021-03-16 /pmc/articles/PMC7962308/ /pubmed/33726702 http://dx.doi.org/10.1186/s12883-021-02120-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Sauder, Torsten
Keune, Philipp M.
Müller, Roy
Schenk, Thomas
Oschmann, Patrick
Hansen, Sascha
Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title_full Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title_fullStr Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title_full_unstemmed Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title_short Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions
title_sort trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (ms): implications for mindfulness-based interventions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962308/
https://www.ncbi.nlm.nih.gov/pubmed/33726702
http://dx.doi.org/10.1186/s12883-021-02120-z
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