The biosynthesis of the cannabinoids

ABSTRACT: Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engin...

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Autores principales: Tahir, M. Nazir, Shahbazi, Fred, Rondeau-Gagné, Simon, Trant, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962319/
https://www.ncbi.nlm.nih.gov/pubmed/33722296
http://dx.doi.org/10.1186/s42238-021-00062-4
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author Tahir, M. Nazir
Shahbazi, Fred
Rondeau-Gagné, Simon
Trant, John F.
author_facet Tahir, M. Nazir
Shahbazi, Fred
Rondeau-Gagné, Simon
Trant, John F.
author_sort Tahir, M. Nazir
collection PubMed
description ABSTRACT: Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with specific cannabinoid profiles. This review surveys the biosynthesis and biochemistry of cannabinoids. The pathways and the enzymes’ mechanisms of action are discussed as is the non-enzymatic decarboxylation of the cannabinoic acids. There are still many gaps in our knowledge about the biosynthesis of the cannabinoids, especially for the minor components, and this review highlights the tools and approaches that will be applied to generate an improved understanding and consequent access to these potentially biomedically-relevant materials. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42238-021-00062-4.
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spelling pubmed-79623192021-03-17 The biosynthesis of the cannabinoids Tahir, M. Nazir Shahbazi, Fred Rondeau-Gagné, Simon Trant, John F. J Cannabis Res Review ABSTRACT: Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with specific cannabinoid profiles. This review surveys the biosynthesis and biochemistry of cannabinoids. The pathways and the enzymes’ mechanisms of action are discussed as is the non-enzymatic decarboxylation of the cannabinoic acids. There are still many gaps in our knowledge about the biosynthesis of the cannabinoids, especially for the minor components, and this review highlights the tools and approaches that will be applied to generate an improved understanding and consequent access to these potentially biomedically-relevant materials. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42238-021-00062-4. BioMed Central 2021-03-15 /pmc/articles/PMC7962319/ /pubmed/33722296 http://dx.doi.org/10.1186/s42238-021-00062-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Tahir, M. Nazir
Shahbazi, Fred
Rondeau-Gagné, Simon
Trant, John F.
The biosynthesis of the cannabinoids
title The biosynthesis of the cannabinoids
title_full The biosynthesis of the cannabinoids
title_fullStr The biosynthesis of the cannabinoids
title_full_unstemmed The biosynthesis of the cannabinoids
title_short The biosynthesis of the cannabinoids
title_sort biosynthesis of the cannabinoids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962319/
https://www.ncbi.nlm.nih.gov/pubmed/33722296
http://dx.doi.org/10.1186/s42238-021-00062-4
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