Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

BACKGROUND: Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recently reported prime editing 2 (PE2) system was carried out...

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Detalles Bibliográficos
Autores principales: Gao, Pan, Lyu, Qing, Ghanam, Amr R., Lazzarotto, Cicera R., Newby, Gregory A., Zhang, Wei, Choi, Mihyun, Slivano, Orazio J., Holden, Kevin, Walker, John A., Kadina, Anastasia P., Munroe, Rob J., Abratte, Christian M., Schimenti, John C., Liu, David R., Tsai, Shengdar Q., Long, Xiaochun, Miano, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962346/
https://www.ncbi.nlm.nih.gov/pubmed/33722289
http://dx.doi.org/10.1186/s13059-021-02304-3

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