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Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()

Serum antibodies play an important role in natural protection from rotavirus infection and disease, but conflicting estimates of association have emerged from epidemiological studies in different geographical settings. In this study, we aim to assess the relationship between pre-existing serum immun...

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Autores principales: Premkumar, Prasanna, Lopman, Ben, Ramani, Sasirekha, Paul, Anu, Gladstone, Beryl, Muliyil, Jayaprakash, Mukhopadhya, Indrani, Parashar, Umesh, Kang, Gagandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962364/
https://www.ncbi.nlm.nih.gov/pubmed/25091682
http://dx.doi.org/10.1016/j.vaccine.2014.04.077
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author Premkumar, Prasanna
Lopman, Ben
Ramani, Sasirekha
Paul, Anu
Gladstone, Beryl
Muliyil, Jayaprakash
Mukhopadhya, Indrani
Parashar, Umesh
Kang, Gagandeep
author_facet Premkumar, Prasanna
Lopman, Ben
Ramani, Sasirekha
Paul, Anu
Gladstone, Beryl
Muliyil, Jayaprakash
Mukhopadhya, Indrani
Parashar, Umesh
Kang, Gagandeep
author_sort Premkumar, Prasanna
collection PubMed
description Serum antibodies play an important role in natural protection from rotavirus infection and disease, but conflicting estimates of association have emerged from epidemiological studies in different geographical settings. In this study, we aim to assess the relationship between pre-existing serum immunoglobulin (Ig)G and IgA titers with protection against rotavirus infection and disease in a birth cohort of Indian children. Children were recruited at birth and followed up for 36 months. Stool samples were collected every 2 weeks and during episodes of diarrhea and serum samples were obtained at least every 6 months. The incidence rate of rotavirus infection and diarrhea was 0.9 (95% CI: 0.88, 0.99) and 0.2 (95% CI: 0.19,0.25) episodes per child year, respectively. The risk of rotavirus infection and diarrhea decreased with age, while antibody titers (IgG and IgA) increased with age. After adjusting for age and number of previous infections, higher levels of IgG and IgA were independently associated with reduced risk of rotavirus infection. However, we did not find a clear association of IgG or IgA with rotavirus diarrhea risk or a threshold level of protection. The study supports a correlation of serum antibodies in reducing the risk of rotavirus infections, however the potential of serum antibody titer as a correlate of protection is not clear for children in lower income settings.
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spelling pubmed-79623642021-03-16 Association of serum antibodies with protection against rotavirus infection and disease in South Indian children() Premkumar, Prasanna Lopman, Ben Ramani, Sasirekha Paul, Anu Gladstone, Beryl Muliyil, Jayaprakash Mukhopadhya, Indrani Parashar, Umesh Kang, Gagandeep Vaccine Article Serum antibodies play an important role in natural protection from rotavirus infection and disease, but conflicting estimates of association have emerged from epidemiological studies in different geographical settings. In this study, we aim to assess the relationship between pre-existing serum immunoglobulin (Ig)G and IgA titers with protection against rotavirus infection and disease in a birth cohort of Indian children. Children were recruited at birth and followed up for 36 months. Stool samples were collected every 2 weeks and during episodes of diarrhea and serum samples were obtained at least every 6 months. The incidence rate of rotavirus infection and diarrhea was 0.9 (95% CI: 0.88, 0.99) and 0.2 (95% CI: 0.19,0.25) episodes per child year, respectively. The risk of rotavirus infection and diarrhea decreased with age, while antibody titers (IgG and IgA) increased with age. After adjusting for age and number of previous infections, higher levels of IgG and IgA were independently associated with reduced risk of rotavirus infection. However, we did not find a clear association of IgG or IgA with rotavirus diarrhea risk or a threshold level of protection. The study supports a correlation of serum antibodies in reducing the risk of rotavirus infections, however the potential of serum antibody titer as a correlate of protection is not clear for children in lower income settings. 2014-08-11 /pmc/articles/PMC7962364/ /pubmed/25091682 http://dx.doi.org/10.1016/j.vaccine.2014.04.077 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Premkumar, Prasanna
Lopman, Ben
Ramani, Sasirekha
Paul, Anu
Gladstone, Beryl
Muliyil, Jayaprakash
Mukhopadhya, Indrani
Parashar, Umesh
Kang, Gagandeep
Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title_full Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title_fullStr Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title_full_unstemmed Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title_short Association of serum antibodies with protection against rotavirus infection and disease in South Indian children()
title_sort association of serum antibodies with protection against rotavirus infection and disease in south indian children()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962364/
https://www.ncbi.nlm.nih.gov/pubmed/25091682
http://dx.doi.org/10.1016/j.vaccine.2014.04.077
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