When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping

BACKGROUND: Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to mutations not only in close proximity to the target site but a...

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Detalles Bibliográficos
Autores principales: Sailer, Sabrina, Coassin, Stefan, Lackner, Katharina, Fischer, Caroline, McNeill, Eileen, Streiter, Gertraud, Kremser, Christian, Maglione, Manuel, Green, Catherine M., Moralli, Daniela, Moschen, Alexander R., Keller, Markus A., Golderer, Georg, Werner-Felmayer, Gabriele, Tegeder, Irmgard, Channon, Keith M., Davies, Benjamin, Werner, Ernst R., Watschinger, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962373/
https://www.ncbi.nlm.nih.gov/pubmed/33726865
http://dx.doi.org/10.1186/s13578-021-00566-9

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