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The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis

BACKGROUND: Abnormal laboratory findings are common in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this systematic review was to investigate the effect of the level of some laboratory factors (C-reactive protein (CRP), creatinine, leukocyte count,...

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Autores principales: Kazemi, Erfan, Soldoozi Nejat, Reihane, Ashkan, Fatemeh, Sheibani, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962428/
https://www.ncbi.nlm.nih.gov/pubmed/33726761
http://dx.doi.org/10.1186/s12941-021-00420-3
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author Kazemi, Erfan
Soldoozi Nejat, Reihane
Ashkan, Fatemeh
Sheibani, Hossein
author_facet Kazemi, Erfan
Soldoozi Nejat, Reihane
Ashkan, Fatemeh
Sheibani, Hossein
author_sort Kazemi, Erfan
collection PubMed
description BACKGROUND: Abnormal laboratory findings are common in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this systematic review was to investigate the effect of the level of some laboratory factors (C-reactive protein (CRP), creatinine, leukocyte count, hemoglobin, and platelet count) on the severity and outcome of coronavirus disease 2019 (COVID-19). METHODS: We searched PubMed, Web of Science, Scopus, and Google Scholar. We collected the articles published before May 26, 2020. We gathered the laboratory factors in groups of patients with COVID-19, and studied the relation between level of these factors with severity and outcome of the disease. RESULTS: Mean CRP level, creatinine, hemoglobin, and the leukocytes count in the critically ill patients were significantly higher than those of the other groups (non-critical patients); mean CRP = 54.81 mg/l, mean creatinine = 86.82 μmol/l, mean hemoglobin = 144.05 g/l, and mean leukocyte count = 7.41 × 10(9). The lymphocyte count was higher in patients with mild/moderate disease (mean: 1.32 × 10(9)) and in the invasive ventilation group (mean value of 0.72 × 10(9)), but it was considerably lower than those of the other two groups. The results showed that the platelet count was higher in critically ill patients (mean value of 205.96 × 10(9)). However, the amount was lower in the invasive ventilation group compared with the other groups (mean level = 185.67 × 10(9)). CONCLUSION: With increasing disease severity, the leukocyte count and the level of CRP increase significantly and the lymphocyte count decreases. There seems to be a significant relation between platelet level, hemoglobin, and creatinine level with severity of the disease. However, more studies are required to confirm this.
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spelling pubmed-79624282021-03-16 The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis Kazemi, Erfan Soldoozi Nejat, Reihane Ashkan, Fatemeh Sheibani, Hossein Ann Clin Microbiol Antimicrob Research BACKGROUND: Abnormal laboratory findings are common in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this systematic review was to investigate the effect of the level of some laboratory factors (C-reactive protein (CRP), creatinine, leukocyte count, hemoglobin, and platelet count) on the severity and outcome of coronavirus disease 2019 (COVID-19). METHODS: We searched PubMed, Web of Science, Scopus, and Google Scholar. We collected the articles published before May 26, 2020. We gathered the laboratory factors in groups of patients with COVID-19, and studied the relation between level of these factors with severity and outcome of the disease. RESULTS: Mean CRP level, creatinine, hemoglobin, and the leukocytes count in the critically ill patients were significantly higher than those of the other groups (non-critical patients); mean CRP = 54.81 mg/l, mean creatinine = 86.82 μmol/l, mean hemoglobin = 144.05 g/l, and mean leukocyte count = 7.41 × 10(9). The lymphocyte count was higher in patients with mild/moderate disease (mean: 1.32 × 10(9)) and in the invasive ventilation group (mean value of 0.72 × 10(9)), but it was considerably lower than those of the other two groups. The results showed that the platelet count was higher in critically ill patients (mean value of 205.96 × 10(9)). However, the amount was lower in the invasive ventilation group compared with the other groups (mean level = 185.67 × 10(9)). CONCLUSION: With increasing disease severity, the leukocyte count and the level of CRP increase significantly and the lymphocyte count decreases. There seems to be a significant relation between platelet level, hemoglobin, and creatinine level with severity of the disease. However, more studies are required to confirm this. BioMed Central 2021-03-16 /pmc/articles/PMC7962428/ /pubmed/33726761 http://dx.doi.org/10.1186/s12941-021-00420-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kazemi, Erfan
Soldoozi Nejat, Reihane
Ashkan, Fatemeh
Sheibani, Hossein
The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title_full The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title_fullStr The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title_full_unstemmed The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title_short The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis
title_sort laboratory findings and different covid-19 severities: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962428/
https://www.ncbi.nlm.nih.gov/pubmed/33726761
http://dx.doi.org/10.1186/s12941-021-00420-3
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