Cargando…

Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro

Cardiotoxicity is one of the main side effects of doxorubicin (Dox) treatment. Dox could induce oxidative stress, leading to an opening of the mitochondrial permeability transition pore (mPTP) and apoptosis in cardiomyocytes. Previous studies have shown that Cryptotanshinone (Cts) has potential card...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiaoping, Sun, Qianbin, Jiang, Qianqian, Jiang, Yanyan, Zhang, Yawen, Cao, Jing, Lu, Linghui, Li, Chun, Wei, Peng, Wang, Qiyan, Wang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962658/ https://www.ncbi.nlm.nih.gov/pubmed/33800264 http://dx.doi.org/10.3390/molecules26051460

Ejemplares similares

Mechanisms and Drug Intervention for Doxorubicin-Induced Cardiotoxicity Based on Mitochondrial Bioenergetics
por: Ling, Guanjing, et al.
Publicado: (2022)

Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy
por: Li, Weili, et al.
Publicado: (2022)

Akt-GSK3β-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress
por: Wu, Danni, et al.
Publicado: (2022)

Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
por: Li, Weili, et al.
Publicado: (2022)

Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway
por: Li, Le, et al.
Publicado: (2020)

Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
por: Tian, Xue, et al.
Publicado: (2022)

TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity
por: Wang, Xiaoping, et al.
Publicado: (2020)

Dipyridamole ameliorates doxorubicin-induced cardiotoxicity
por: Alyasiry, Esraa, et al.
Publicado: (2022)

Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity
por: Li, Weili, et al.
Publicado: (2021)

Apelin-13 protects the heart against ischemia-reperfusion injury through the RISK-GSK-3β-mPTP pathway
por: Yang, Shuansuo, et al.
Publicado: (2015)

Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis
por: Shi, Hongwei, et al.
Publicado: (2021)

Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats
por: Jiang, Yifang, et al.
Publicado: (2019)

Sirt3 targets mPTP and prevents aging in the heart
por: Sadoshima, Junichi
Publicado: (2011)

Corrigendum: Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis
por: Shi, Hongwei, et al.
Publicado: (2021)

Promising Strategy of mPTP Modulation in Cancer Therapy: An Emerging Progress and Future Insight
por: Waseem, Mohammad, et al.
Publicado: (2023)

RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway
por: Jiao, Yuheng, et al.
Publicado: (2022)

Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice
por: Wang, Kaixin, et al.
Publicado: (2021)

Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3
por: Zhang, Wei, et al.
Publicado: (2023)

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells
por: Zhang, Rong, et al.
Publicado: (2018)

Role of acetylation in doxorubicin-induced cardiotoxicity
por: Li, Daisong, et al.
Publicado: (2021)

Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway
por: Hu, Xiaoliang, et al.
Publicado: (2022)

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway
por: Zhan, Lan, et al.
Publicado: (2021)

Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity
por: Majhi, Sagarika, et al.
Publicado: (2022)

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
por: Wang(a), Jie, et al.
Publicado: (2022)

Mitochondrial DNA Efflux Maintained in Gingival Fibroblasts of Patients with Periodontitis through ROS/mPTP Pathway
por: Liu, Jia, et al.
Publicado: (2022)

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
por: Kim, Sang-A, et al.
Publicado: (2018)

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling
por: Ren, Dezhi, et al.
Publicado: (2020)

ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening
por: Xu, Tao, et al.
Publicado: (2018)

Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria
por: Azarashvili, Tamara, et al.
Publicado: (2016)

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells
por: Teixeira, José, et al.
Publicado: (2017)

Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening
por: Baburuna, Yulia, et al.
Publicado: (2021)

Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α
por: Shen, Yihui, et al.
Publicado: (2022)

Chrysanthemum morifolium Extract Ameliorates Doxorubicin-Induced Cardiotoxicity by Decreasing Apoptosis
por: Ono, Masaya, et al.
Publicado: (2022)

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats
por: Samir, Rania, et al.
Publicado: (2023)

Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
por: Wang, Xiaoping, et al.
Publicado: (2019)

Low dose radiation prevents doxorubicin-induced cardiotoxicity
por: Jiang, Xin, et al.
Publicado: (2017)

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells
por: Huo, Haizhong, et al.
Publicado: (2016)

Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
por: Ferko, Miroslav, et al.
Publicado: (2019)

Nicorandil Ameliorates Doxorubicin-Induced Cardiotoxicity in Rats, as Evaluated by 7 T Cardiovascular Magnetic Resonance Imaging
por: Wan, Yixuan, et al.
Publicado: (2021)

Setanaxib (GKT137831) Ameliorates Doxorubicin-Induced Cardiotoxicity by Inhibiting the NOX1/NOX4/Reactive Oxygen Species/MAPK Pathway
por: Zheng, Hui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fhrkn1b5t8c1ckdbe50lrs8ckg