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Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study

BACKGROUND: Cancer-related cognitive decline (CRCD) has been linked to apolipoprotein E (APOE) gene ε4 polymorphisms. APOE ε4 polymorphisms are also the strongest genetic risk for late-onset Alzheimer disease (AD), whereas ε2 polymorphisms protect against AD. However, the effects of ε2 polymorphisms...

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Detalles Bibliográficos
Autores principales: Van Dyk, Kathleen, Zhou, Xingtao, Small, Brent J, Ahn, Jaeil, Zhai, Wanting, Ahles, Tim, Graham, Deena, Jacobsen, Paul B, Jim, Heather, McDonald, Brenna C, Nudelman Holohan, Kelly, Patel, Sunita K, Rebeck, G William, Root, James C, Saykin, Andrew J, Cohen, Harvey Jay, Mandelblatt, Jeanne S, Carroll, Judith E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962698/
https://www.ncbi.nlm.nih.gov/pubmed/33748669
http://dx.doi.org/10.1093/jncics/pkab013